Results 71 to 80 of about 1,560,902 (263)

Digital reference service management systems in libraries

Cybrarians Journal, 2012
A study on digital reference service management software in libraries. The study begins with a methodological introduction that addresses the objectives of the research, its terminology, and previous studies.
Mahmoud Khalifa
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reference Systems

Journal of the Royal College of Physicians of London, 1992
Bernhard Hofmann-Wellenhof, Herbert Lichtenegger, James Collins   +2 more
openaire   +3 more sources

Rapid reagent free COVID19 detection using MEMS based FTIR spectroscopy and machine learning in NIR and MIR regions

Scientific Reports
This study presents rapid, reagent-free detection of COVID-19 using miniaturized MEMS-based Fourier-transform infrared (FTIR) spectrometers integrated with machine learning models. Two portable spectrometers analyze 363 nasopharyngeal swab samples stored
Ahmed Abdelkhalik, Mazen Erfan, Bassem Mortada, Mohamed Gaber, Shereen Saeed, Ghada Ismail, Ahmed ElShafei, MennaAllah S. Mohamed, Bassam Saadany, Yasser M. Sabry, Diaa Khalil   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Increased HIV and other sexually transmitted infections in two health facilities in Northern Cameroon between 2021 and 2022

Journal of Public Health in Africa
Background: Human immunodeficiency viruses (HIV) and acquired immunodeficiency syndrome (AIDS) remain a global public health problem. Other sexually transmitted infections (STIs) are aggravating factors.
Patrice Djataou, Marceline D. Ngounoue, Georges Nguefack-Tsague, Jean de Dieu Anoubissi, Joséphine J.K. Kadji, Tiga A. Aline, Elise Elong, Moussa Djaouda, Alexis Ndjolo, Celine N. Nkenfou   +9 more
doaj   +1 more source

Intrinsic references in distributed systems [PDF]

Proceedings 22nd International Conference on Distributed Computing Systems Workshops, 2003
The notion of intrinsic references, i.e. references based on the hash digest of the referent, is introduced and contrasted with that of physical references, where the referent is defined relative to the state of a physical system. A retrieval mechanism using intrinsic references, the Elephant Store, is presented.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source