Results 141 to 150 of about 2,480,958 (257)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Assessment of blood lead reference values for the Southern Ghanaian population against the background of international recommendations. [PDF]

Int Arch Occup Environ Health
Consoir L, Arko-Mensah J, Bertram J, Fobil JN, Heussen N, Schettgen T, Lakemeyer M, Heggie T, Küpper T.   +8 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reference Values for Cardiopulmonary Exercise Test in Children-How to Report Them Correctly? [PDF]

J Clin Med
Kasiak P.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Determination of reference values of figure of 8 walk walk test in healthy adults. [PDF]

Ir J Med Sci
Katirci Kirmaci ZI, Gözaçan Karabulut D, Maden Ç, Elpeze G, Kirmaci YŞ, Yildirim H, Gün Kalkin T.   +6 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Standardization of coagulometric tests in griffon vultures (<i>Gyps fulvus</i>): PT, aPTT and factor V reference values. [PDF]

Front Vet Sci
De Pablo-Moreno JA, Miguel-Batuecas A, Carretero J, González F, Alvarado-Piqueras A, Fuertes-Recuero M, García JA, Revuelta L.   +7 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Age- and Sex-Specific Distribution and Reference Values of Coronary Artery Calcium in a Large Asymptomatic Japanese Cohort. [PDF]

J Am Heart Assoc
Takagi H, Hirano M, Asano T, Nishimiya K, Obara T, Ota H, Taguchi J, Takase K.   +7 more
europepmc   +1 more source