Results 171 to 180 of about 8,013 (292)

Aidification of the self: a phenomenological approach to machine consciousness through human-robot 'between-ness'. [PDF]

Neurosci Conscious
Tanaka S.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A `Self-Referential' Weight Matrix

, 2007
Weight modifications in traditional neural nets are computed by hard-wired algorithms. Without exception, all previous weight change algorithms have many specific limitations. Is it (in principle) possible to overcome limitations of hard-wired algorithms
Jürgen Schmidhuber
core  

A concentric tube catheter for endoluminal interventions, steered and imaged via magnetic resonance imaging. [PDF]

Commun Eng
Lloyd P, Murasovs N, May YL, Bacchetti A, Calmé B, Davy J, Francescon V, Chandler JH, Dall'Armellina E, Schneider JE, Valdastri P.   +10 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Somatic Engram and Reversal of Allostatic Load via Reconsolidation: A Technical Description of the RB7™ Protocol. [PDF]

Cureus
Barreiros RM.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Relational Databases for Behavior Science. [PDF]

Perspect Behav Sci
Soto PL.
europepmc   +1 more source

Hardening of Network Segmentation Using  Automated Referential Penetration Testing

Journal of Network and Computer Applications, 2023
Mohammed Alabbad, Neerja Mhaskar, Ridha Khédri   +2 more
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source