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TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source
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Referential and Non-referential Uses of the Third Person Pronominal Subject in Spanish

Journal of Psycholinguistic Research, 2017
This paper studies the role of two different types of motivation that have been proposed to explain the use of subject personal pronouns in Spanish, namely their function as indications for the addressee to identify the subject's referent, and their suitability for expressing informational values such as contrastiveness or focus.
Marcos Garcia Salido
exaly   +3 more sources

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