Results 101 to 110 of about 2,877,856 (360)
An evidence-based approach to the urgent referral of suspected oral cancer in England
, 2021 Background Reports that UK outcomes for several cancers, including oral, were inferior to comparable European countries prompted the UK Government’s ‘NHS Cancer Plan’; a central aim was reduction of late presentation.
Langton, Stephen G.
core +1 more source
South African Family Practice, 2008 The family practitioner in private practice is a key role player within the primary health care system and should play a bigger role in national tuberculosis (TB) control.
Norbert O. Ndjeka +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cancer, 2014 Limited data are available on how the timing and setting of palliative care (PC) referral can affect end‐of‐life care. In this retrospective cohort study, the authors examined how the timing and setting of PC referral were associated with the quality of ...
D. Hui +5 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Oral referral: On the mislocalization of odours to the mouth
, 2016 Oral referral is central to multisensory flavour perception. The phenomenon, first described a little over a century ago, is characterized by the mislocalization of food-related olfactory stimuli to the oral cavity.
C. Spence
semanticscholar +1 more source
Recommendations for Diagnosis, Referral for Liver Biopsy, and Treatment of NAFLD and NASH
Mayo Clinic proceedings, 2015 Nonalcoholic fatty livery disease (NAFLD) is the primary cause of chronic liver disease in the United States, afflicting an estimated 80–100 million Americans.
Erin Spengler, R. Loomba
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Early management of head injury in adults in primary care [PDF]
Malaysian Family Physician, 2017 Head injury is common and preventable. Assessment of the head injury patient includes airway, cervical spine protection, breathing, circulation, haemorrhage control and the Glasgow Coma Scale.
Liew Boon Seng +4 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source