Results 111 to 120 of about 2,877,856 (360)
BMJ, 1994 The implementation of the British National Health Service in 1948 as a system based on generalists, with general practitioners as the gatekeepers to secondary care, institutionalised the separation of primary and secondary care. Since then it has proved a cost effective model,1,2 emulated by several health maintenance organisations in the United States
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Physician And Patient Barriers To Radiotherapy Service Access: Treatment Referral Implications
Cancer Management and Research, 2019 Sara Chierchini,1 Gianluca Ingrosso,1 Simonetta Saldi,1 Fabrizio Stracci,2 Cynthia Aristei1 1Radiation Oncology Section, Department of Surgical and Biomedical Sciences, University of Perugia and Perugia General Hospital, Perugia, Italy; 2Department of ...
Chierchini S +4 more
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of Pain ResearchAimee K Hildenbrand,1– 3 Christina M Amaro,1,4 Benjamin Bear,1 Catherine M Soprano,3,5 Katherine S Salamon2,3 1Center for Healthcare Delivery Science, Nemours Children’s Health, Wilmington, DE, USA; 2Division of Behavioral Health, Nemours Children’s ...
Hildenbrand AK +4 more
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Referral practices of rural primary care physicians for patients with depression [PDF]
, 2001 Plan BThis research characterizes the treatment and referral practices of rural primary care physicians for their patients with depression. A mailed survey was sent to all practicing physicians in rural Jackson County, Wisconsin and surrounding areas ...
Wentz, Meridith K.
core
First quality score for referral letters in gastroenterology—a validation study [PDF]
, 2016 Objective To create and validate an objective and reliable score to assess referral quality in gastroenterology. Design An observational multicentre study.
Hovde, Øistein +11 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source