Results 141 to 150 of about 3,411,222 (260)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Correlation Between Referred Pain Region and Sensitized Acupoints in Patients with Stable Angina Pectoris and Distribution of Sensitized Spots in Rats with Myocardial Ischemia

针刺研究, 2018
Objective To observe the correlation between the referred pain regions of stable angina pectoris(SAP)and the acupoints in coronary heart disease(CHD)patients and to investigate the rule of regional sensitized point distribution in rats.Methods A total of
SHI Jing, WANG Jian, WANG Yuan, LIU Kun, FU Yong, SUN Jian-hua, ZHAO Ji-ping, SHAO Xiao-mei, FENG Si-feng, YANG You-wei, LI Jie, CAO Qian-an, HE Xun, LIU Mei-fang, CHEN Lu, CUI Xiang, WU Jiang-yun, WU Yuan-yuan, GAO Xin-yan, ZHU Bing   +19 more
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Screening for asthma among women referred for fertility treatment using a symptom questionnaire and fractional exhaled nitric oxide. [PDF]

Eur Clin Respir J
Miller ON, Hansen AV, Tidemandsen C, Huang EY, Freiesleben NC, Backer V, Suppli Ulrik C.   +6 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Mild Cognitive Impairment Identification in Geriatric and Primary Care Clinics and Driving Assessment Outcomes. [PDF]

Cureus
Moshiri KA, Mahmodian M.
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Diaphragmatic breathing for referred pain after total laparoscopic hysterectomy: a randomized clinical trial

[Background] Referred cervicoscapular pain is common after laparoscopic surgery. This pain has different characteristics from incisional pain and requires a different approach.[Method] A blinded, randomized, controlled trial was conducted.
Fernández-Domínguez, Juan Carlos, Melero Cortés, Lidia María, Pabón-Carrasco, Manuel, Partida-Márquez, Antonio Luis, Martínez-Fernández, José Antonio, Oliva Pascual Vaca, Ángel   +5 more
core   +1 more source