Results 51 to 60 of about 2,382 (289)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Distributional Refinement Network: Distributional Forecasting via Deep Learning
A key task in actuarial modelling involves modelling the distributional properties of losses. Classic (distributional) regression approaches like Generalized Linear Models (GLMs; Nelder and Wedderburn, 1972) are commonly used, but challenges remain in developing models that can (i) allow covariates to flexibly impact different aspects of the ...
Avanzi, Benjamin +3 more
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Nonhomogeneous Wavelet Systems in High Dimensions [PDF]
, 2010 It is of interest to study a wavelet system with a minimum number of generators. It has been showed by X. Dai, D. R. Larson, and D. M. Speegle in [11] that for any $d\times d$ real-valued expansive matrix M, a homogeneous orthonormal M-wavelet basis can ...
Han, Bin
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Refinable functions for dilation families [PDF]
, 2018 We consider a family of d × d matrices W e indexed by e ∈ E where (E, μ) is a probability space and some natural conditions for the family (W e ) e ∈ E are satisfied.
Grohs, Philipp
core
Refinement-based Construction of Correct Distributed Algorithms
2021 Second International Conference on Information Systems and Software Technologies (ICI2ST), 2021 The verification of distributed algorithms is a challenge for formal techniques supported by tools, as model checkers and proof assistants. The difficulties, even for powerful tools, lie in the derivation of proofs of required properties, such as safety and eventuality, for distributed algorithms. Verification by construction can be achieved by using a
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Improved bounds for the rate loss of multiresolution source codes [PDF]
, 2003 We present new bounds for the rate loss of multiresolution source codes (MRSCs). Considering an M-resolution code, the rate loss at the ith resolution with distortion D/sub i/ is defined as L/sub i/=R/sub i/-R(D/sub i/), where R/sub i/ is the rate ...
Effros, Michelle, Feng, Hanying
core
Compactly supported multi-refinable distributions and B-splines
Journal of Mathematical Analysis and Applications, 2006 Let \(\lambda >0\) and \(\mu >0\) be given. A compactly supported distribution \(\varphi\) is called \(\lambda\)-refinable, if \[ \varphi(x)=\sum_{j=-\infty}^{\infty} c_j\,\varphi( \lambda x - d_j), \] where \(\{j\in {\mathbb Z}; \,c_j\neq 0\}\) is finite and \[ \sum_{j=-\infty}^{\infty} c_j= \lambda. \] If \(\varphi\) is both \(\lambda\)-refinable and
openaire +1 more source