Results 41 to 50 of about 3,273 (138)
An uncertainty approach to modelling climate change risk in South Africa [PDF]
, 2015 This study represents the first attempt at an integrated approach to assessing the potential impacts of climate change on the national economy of South Africa via a number of (but not necessarily all) impact channels.
Alton, Theresa +13 more
core +1 more source
ChemMedChem, Volume 21, Issue 5, 13 March 2026.This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica +16 more
wiley +1 more source
Human cytochrome b5 reductase: structure, function, and potential applications [PDF]
, 2014 Cytochrome b5 reductase is a flavoprotein that is produced as two different isoforms that have different localizations. The amphipathic microsomal isoform, found in all cell types with the exception of erythrocytes, consists of one hydrophobic membrane-
Elahian, F. +3 more
core
Citrulline and intestinal fatty acid-binding protein as biomarkers for gastrointestinal dysfunction in the critically ill [PDF]
, 2019 Currently there is no reliable tool available to monitor gastrointestinal function in the critically ill. Biomarkers are therefore of great interest in this field as the lack of monitoring tools impedes any interventional studies.
Blaser, Annika +4 more
core +1 more source
Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling
Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes +2 more
wiley +1 more source
The Performance of Several Docking Programs at Reproducing Protein-Macrolide-Like Crystal Structures [PDF]
, 2017 The accuracy of five docking programs at reproducing crystallographic structures of complexes of 8 macrolides and 12 related macrocyclic structures, all with their corresponding receptors, was evaluated.
Castro Álvarez, Alejandro +2 more
core +2 more sources
European Journal of Pain, Volume 30, Issue 3, March 2026.ABSTRACT Background Neuropathic pain (NP) is a complex chronic condition with limited therapeutic effectiveness. Despite multiple drug classes and international guidelines, real‐world adherence remains inconsistent, and data on prescribing practices among pain specialists is scarce. Methods We conducted a nationwide cross‐sectional survey among members
Miguel Á. Huerta +17 more
wiley +1 more source
Local scale assessment of climate change and its impacts in the Highlands and Islands of Scotland [PDF]
, 2007 The global climate is warming and there is consensus that recent warming trends will amplify, as the present century progresses, in response to a continued build up of atmospheric greenhouse gas (GHG) concentrations.
Coll, John
core +1 more source
WIREs Climate Change, Volume 17, Issue 2, March/April 2026.Review of the uncertainty sampling and its propagation across the flood risk modeling chain. ABSTRACT This systematic review examines how uncertainty is sampled and propagated through interconnected model chains in climate‐induced flood risk assessments.
Villy Mik‐Meyer +4 more
wiley +1 more source
The role and place of ECEC in integrated working benenfitting vulnerable groups such as Roma [PDF]
, 2019 The main purpose of this report is to examine the added value provided by, and the prerequisites for, integrated working – as well as the crucial role played by ECEC services – in order to better serve all families, but especially vulnerable and ...
Hulpia, Hester +4 more
core +1 more source