Results 101 to 110 of about 297,066 (279)

International Refinement Workshop and Formal Methods Pacific ’98

, 1998
The International Refinement Workshop and Formal Methods Pacific 1998 (IRW/FMP'98), as the title suggests, is a combined event. FMP'98 itself incorporates the 7th Australasian Refinement Workshop and the 4th New Zealand Formal Program Development ...
Australasian Refinement Workshop, New Zealand Formal Program Development Colloquium, International Refinement Workshop and Formal Methods Pacific   +2 more
core  

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Using NMR Chemical Shifts and Cryo-EM Density Restraints in Iterative Rosetta-MD Protein Structure Refinement

, 2019
Cryo-EM has become one of the prime methods for protein structure elucidation, frequently yielding density maps with near-atomic or medium resolution. If protein structures cannot be deduced unambiguously from the density maps, computational structure ...
Sumudu P. Leelananda (4470238), Steffen Lindert (115057)   +1 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Peptide bonds revisited

IUCrJ
Understanding the structural and chemical properties of peptide bonds within protein secondary structures is vital for elucidating their roles in protein folding, stability and function.
Santosh Panjikar, Manfred S. Weiss
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

REFMAC5 for the refinement of macromolecular crystal structures [PDF]

, 2011
This paper describes various components of the macromolecular crystallographic refinement program REFMAC5, which is distributed as part of the CCP4 suite.
Robert A. Nicholls, Long F, Garib N. Murshudov, Steiner, Roberto A., Long, Fei, Roberto A. Steiner, Nicholls, Robert A., Murshudov, Garib Novruz, Navraj S. Pannu, Nicholls R. A., Lebedev AA, Winn M. D., Pavol Skubák, Winn, Martyn D., Lebedev, Andrey, Vagin AA, Lebedev A. A., Murshudov GN, Skubak P., Nicholls, Robert Adam, Fei Long, Steiner R., Murshudov, Garib N., Skubak P, Long F., Winn MD, Nicholls RA, Pannu, Navraj S., Pannu NS, Andrey A. Lebedev, Skubak, Pavol, Steiner RA, Pannu N. S., Alexei A. Vagin, Vaguin, Alexei A., Vagin A. A., Martyn D. Winn, Murshudov G. N., Lebedev, Andrey A., Vagin, Alexei A.   +39 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Grain refinement efficiency of a new oxide-containing master alloy for aluminium casting alloys [PDF]

, 2014
In this study, grain refinement efficiency of a new oxide master alloy based on MgAl2O4 was demonstrated on an A357 alloy. The grain size of the reference alloy was reduced by 50-60% with the addition of the master alloy and introduction of ultrasonic ...
Dmitry G. Eskin, Vadakke Madam Sreekumar, Nadendla Hari Babu, Sreekumar, VM, Babu, NH, Eskin, DG, Fan, ZY, Zhong Yun Fan   +7 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source