Results 221 to 230 of about 828,177 (293)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

High-Purity Copper Recovery from Copper Sludge via Oxidative Refining Using a FeO-CaO-SiO₂ Slag System. [PDF]

Materials (Basel)
Park E, Kim M, Kim YM, Kim YH.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refining Cannabinoid Ratios for Geriatric Pain: Methodological and Clinical Reflections on the CARE Study [Letter]. [PDF]

J Pain Res
Qiang D, Zheng C, Xu Y.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

From counting to clustering: AI-defined "diffuse" vs. "focal" spatial patterns as the new precision biomarker for triple-negative breast cancer. [PDF]

Front Immunol
Cai L, Li P.
europepmc   +1 more source

Efficient Electrolytic Refining of Crude Solder Assisted by Additives in a Fluosilicic Acid System. [PDF]

Materials (Basel)
Yang Y, Wang Z, Wang X, Xu W, Yuan H, Liu Q, Xu R, Yang L.   +7 more
europepmc   +1 more source

Neurophysiological Responses to Extra Virgin and Refined Olive Oils: A Pilot Study Combining Flavor Profiling, Electroencephalogram, and Standardized Low-Resolution Brain Electromagnetic Tomography. [PDF]

Food Sci Nutr
Moon HS, Yu SY, Park H, Ban Y, Kim JS, Shin EC.   +5 more
europepmc   +1 more source

Refining Free Light Chain Ratio in Systemic Amyloidosis. [PDF]

JACC CardioOncol
Zhang Z, Guo Q, Gao Y, Li M, Ma C.
europepmc   +1 more source