Results 71 to 80 of about 80,097 (310)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

In situ measurement of the spectral reflectance of mirror-like metallic surfaces during plasma exposition

Nuclear Materials and Energy, 2018
Visible spectroscopy in fusion plasmas crucially depends on the optical properties of first mirrors withstanding a considerable amount of radiation and particle fluxes.
Sven Dickheuer, Oleksandr Marchuk, Stephan Ertmer, Andrei Goriaev, Mykola Ialovega, Beatrix Göths, Yury Krasikov, Philippe Mertens, Arkadi Kreter   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Scaling spectroscopic approaches – from leaf albedo to ecosystems mapping [PDF]

, 2010
Field based spectroscopy for ecological and environmental monitoring has become an indispensable part of complete observational systems as defined in GEOSS (Global Earth Observation System of Systems).
Malenovský, Z, Bartholomeus, H, Schaepman, M.E., Malenovsky, Z., Schaepman-Strub, G, Schaepman, Michael E; https://orcid.org/, Bartholomeus, H., Hueni, A., Schaepman-Strub, G., Kneubühler, M; https://orcid.org/, Damm, A; https://orcid.org/, Kneubühler, M., Damm, A.   +12 more
core   +1 more source

Effects of Atmospheric, Topographic, and BRDF Correction on Imaging Spectroscopy-Derived Data Products

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Surface reflectance is an important data product in imaging spectroscopy for obtaining surface information. The complex retrieval of surface reflectance, however, critically relies on accurate knowledge of atmospheric absorption and scattering, and the ...
Marius Vogtli, Daniel Schlapfer, Meredith C. Schuman, Michael E. Schaepman, Mathias Kneubuhler, Alexander Damm   +5 more
doaj   +1 more source

Notes and Reflections on Impedance Spectroscopy

Pharmaceutica Analytica Acta, 2017
Fil: Frechero, Marisa Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Bahia Blanca. Instituto de Quimica del Sur. Universidad Nacional del Sur. Departamento de Quimica.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Rapid measurement of polycyclic aromatic hydrocarbon contamination in soils by visible and near-infrared spectroscopy [PDF]

, 2013
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed organic pollutants. At petroleum contaminated sites, PAHs are often the key risk drivers because of their carcinogenicity. Assessing the risk of PAH at contaminated sites by conventional soil
Okparanma, Reuben N.
core