Results 51 to 60 of about 122,051 (265)

Now and then : reflections on practice

open access: yesScottish Journal of Residential Child Care, 2018
This reflective paper was inspired by the SJRCC special edition on history. The paper focusses on the experiences of the authors as residential child care workers in the 1970s, 80s and 90s in Scotland. Having worked together in two different group care settings, they used their own experiences and relationship to reflect on the 'Now and Then' – what ...
Cran, Jean, Stevens, Irene
openaire   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Action Research for Reflective Practice: Could a Database of Approaches Help?

open access: yesHOW, 2016
In an earlier paper (Cousin, 1997a) the use of action research in a postgraduate programme of "Specialist in Education with emphasis on the teaching of English" of the University of Tolima was described and attempt made to justify the constraints on ...
William D. Cousin
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pre-Service English Teachers’ Perceptions Towards The Use of Dialogical Learning as Reflective Practice: A Case Study

open access: yesSALEE
In the context of English as a Foreign Language (EFL) teacher education, reflective practice is an integral part of the development of pedagogical practices, yet challenges persist in its effective implementation.
Wulandari Santoso   +1 more
doaj   +1 more source

Reflective practice and conscientisation [PDF]

open access: yesPedagogy, Culture and Society, 1999
AbstractBoth ‘the reflective teaching’ and ‘the teacher as a reflective practitioner’ have become very popular In terms of the literature about the teachIng and training profession, In spIte of ambiguIties and misleading Ideas. Thus, it is of the greatest Importance to analyse these ambiguities by questioning the words used, the relations of power ...
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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