Results 81 to 90 of about 894,741 (304)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Clinical psychologists’ use of reflection and reflective practice within clinical work [PDF]

, 2015
Previous research regarding reflective practice has considered the training and development of reflective skills; little attention has been paid to how these are used by clinicians in practice.
Bennett-Levy J., Bolton G., British Psychological Society (BPS), Brown D., Cushway D., Cushway D., Division of Clinical Psychology, Gillmer B., Kimberly Chew, Lavender T., Lavender T., Lim P. H., O’Loughlin S., Paul Fisher, Paula C., Schön D. F., Smith J. A., Stedmon J., Tan A. G., Yi Jin Leow   +19 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Relevance of Rigour for Design Practise [PDF]

, 2009
Design is an inverted discipline. The concept of rigour, as understood within the natural sciences, cannot be applied to Design Practice. Rigour for the natural sciences is a quality assurance mechanism ensuring that the knowledge bases of the ...
Spencer, Nick
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Action Research for Reflective Practice: Could a Database of Approaches Help?

HOW, 2016
In an earlier paper (Cousin, 1997a) the use of action research in a postgraduate programme of "Specialist in Education with emphasis on the teaching of English" of the University of Tolima was described and attempt made to justify the constraints on ...
William D. Cousin
doaj  

Promoting and investigating students’ uptake of reflective practice: A Pakistan case [PDF]

, 2005
Today reflection is considered one of the essential principles underlying good teaching practice and teacher education. However, this tacit acknowledgement that teachers need to be reflective practitioners and the development of reflective practice has ...
Rarieya, Jane
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Enhancing skills of critical reflection to evidence learning in professional practice [PDF]

, 2013
Professional organisations and regulatory bodies are making critical reflection a mandatory component of professional practice. Reflection is a vital part of learning from experience and is central to developing and maintaining competency across a ...
Benner, Biesta, Biesta, Bulley, Colin Paterson, Donaghy, Dreyfus, Duffy, Erben, Ertmer, Gadamer, Ghaye, Gibbs, Habermas, Higgs, Jasper, Jensen, Johns, Jones, Judith Chapman, King, Kolb, Mann, Mezirow, Moon, Moon, Ricoeur, Rivett, Roberts, Rolfe, Rolfe, Schön, Schön   +32 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source