Results 101 to 110 of about 1,363,664 (291)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Recognizing the Known Unknowns; the Interaction Between Reflective Thinking and Optimism for Uncertainty Among Software Developer's Security Perceptions. [PDF]

Technol Mind Behav, 2023
Ivory M, Towse J, Sturdee M, Levine M, Nuseibeh B.   +4 more
europepmc   +1 more source

Prospective Science Teachers’ Tendecies of Reflective Thinking and Views About Reflective Thinking

İlköğretim Online, 2023
The purpose of this study is to evaluate how prospective science teachers ‘ perceive reflectivethinking and their tendency of reflective thinking who were enrolled in all grade levels at Sakarya University Faculty of Education. The research model was selected as survey research model and the study group of the study is constitutes of 180 students. Data
Şule Elmalı, Şule Elmalı, Fatime Balkan Kıyıcı   +2 more
openaire   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

An empirical analysis: The impact of project-based learning on students' mathematical reflective thinking skills and self-concept

Indonesian Journal of Science and Mathematics Education
Mathematical reflective thinking skills and self-concept are essential aspects of 21st-century learning to address global challenges. This study analyzes the effect of Project-Based Learning (PjBL) on students' mathematical reflective thinking skills and
Sri Hastuti Noer, Mella Triana, Pentatito Gunowibowo, Rini Asnawati, Wanda Vetama   +4 more
doaj   +1 more source

Reflective Thinking Skills of Academic Administrators in Higher Education. [PDF]

Front Psychol, 2022
Kasalak G, Dağyar M, Özcan M, Yeşilyurt E.   +3 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Finding Ourselves at the margins: The Integration of Self-Care Reflective work into contextual Education [PDF]

Formation for ministry has long been a focus of study within theological education.  Essential to ministry formation is the development of self-preserving practices that promote renewal and flourishing.
Woodbury-Moore, Christy
core  

The effect of e-portfolio application on reflective thinking and learning motivation of primary school teacher candidates. [PDF]

Curr Psychol, 2022
Ayaz M, Gök B.
europepmc   +1 more source