Results 291 to 300 of about 557,831 (338)

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel   +10 more
wiley   +1 more source

Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether the ratio between motor evoked potential (MEP) amplitude, reflecting upper motor neuron integrity, and compound ...
Federico Ranieri   +41 more
wiley   +1 more source

Gait Analysis During Paralysis Recovery in a Rat Incomplete Spinal Cord Injury Model. [PDF]

open access: yesJOR Spine
Toyota M   +6 more
europepmc   +1 more source

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali   +7 more
wiley   +1 more source

Hochdrucksynthese kristalliner doppelschichtiger Kohlenstoffnitrid‐Netzwerke stabilisiert in Bi7C10N18(N3(1‐x)O3x)

open access: yesAngewandte Chemie, EarlyView.
High‐pressure chemical reaction between Bi and various hydrogen‐free C‐N precursors induced by the infrared laser heating in a diamond anvil cell, leads to the formation of a compound Bi7C10N18(N3(1‐x)O3x), featuring double layers of poly‐N‐(1,3,5‐triazin‐2‐yl)‐guanidine [C4N6x‐]n and non‐polymerized guanidinate anions CN35‐.
Lukas Brüning   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy