Results 241 to 250 of about 425,087 (345)

Reflux Esophagitis*

open access: yesAnnals of Surgery, 1955
J D, STEWART, W M, CHARDACK, G S, ALFANO
openaire   +3 more sources

Synthesis of Multisubstituted Pyranoindol‐1‐ones Using Iridium‐Catalyzed Intramolecular C─H Amination of 3‐Amino‐4‐phenyl‐2‐pyrones

open access: yesAsian Journal of Organic Chemistry, EarlyView.
A method for the synthesis of multisubstituted pyranoindol‐1‐ones is developed, utilizing iridium‐catalyzed intramolecular C─H amination of 3‐amino‐4‐phenyl‐2‐pyrones synthesized via the conjugate addition of diethyl 2‐aminomalonate to alkynyl ketones. This synthetic strategy was successfully applied to the synthesis of analogues of biologically active
Ren Yamasaki   +3 more
wiley   +1 more source

Patient‐Specific Coculture of S. aureus and P. aeruginosa Enhances Epithelial Barrier Disruption and Virulence in CRS

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease that is associated with polymicrobial infections, often involving S. aureus and P. aeruginosa. It is unclear whether the polymicrobial context plays a role in exacerbating epithelial damage, inflammation, and resistance to therapy. Methods S. aureus and P. aeruginosa (n =
Xiaohan Sun MMed   +6 more
wiley   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai   +7 more
wiley   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

open access: yesAngewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann   +10 more
wiley   +1 more source

Hewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study. [PDF]

open access: yesJ Tradit Chin Med
Xiaosi Z   +6 more
europepmc   +1 more source

Self-Reported Dysphagia and Laryngopharyngeal Reflux among a Community-Dwelling Elderly Rural Population. [PDF]

open access: yesInt Arch Otorhinolaryngol
Sideris G   +5 more
europepmc   +1 more source

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