Results 91 to 100 of about 3,063,283 (292)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

open access: yesAdvanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng   +12 more
wiley   +1 more source

GRAPHICAL CALCULATION METHOD FOR MINIMUM REFLUX RATIO IN AZEOTROPIC DISTILLATION

open access: yesJOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 1972
In an azeotropic distillation column, the rate of net flow and the composition of net flow for both stripping and rectifying sections can be calculated from the limiting conditions of the separation desired. The pinch points are dotted on the radial lines starting from the point of net flow composition by trial and error, and locus of the pinch points ...
TANAKA, SHOZO, YAMADA, JIRO
openaire   +2 more sources

Hybrid Metal–Organic Framework‐Derived Dual Active Site Catalysts Enabling Surface‐Enriched Cathode and Modified Zinc Anode for Long‐Life Zinc–Air Batteries

open access: yesAdvanced Science, EarlyView.
This work demonstrates the implementation of MOF‐assisted anode and cathode materials for prolonged cycling of zinc‐air batteries with strong redox capability and structural stability. ABSTRACT The surface modification of zinc anodes and the development of effective cathode dual‐functional oxygen electrocatalysts remain of paramount interest for ...
Ramasamy Santhosh Kumar   +7 more
wiley   +1 more source

Case Studies on Optimum Reflux Ratio of Distillation Towersin Petroleum Refining Processes

open access: yes, 2011
For an existing distillation tower such as the propylene splitter in this study, the number of trays is fixed and there are very few degrees of freedom that can be manipulated to maximize operating profit; the reflux ratio can be used to influence the ...
Chen, Hsi-jen; Lin, Yeh-chin
core   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

open access: yesAdvanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang   +8 more
wiley   +1 more source

Optimization of operating parameters for furfuryl alcohol production in a reactive distillation column using response surface methodology

open access: yesResults in Chemistry
Furfuryl alcohol is an important platform chemical with a wide range of industrial applications. In this study, the optimization of operating parameters for the production of furfuryl alcohol in a reactive distillation column was investigated using ...
Ali Akbar Amooey
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

open access: yesAdvanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang   +15 more
wiley   +1 more source

Determination and comparison of mean random urine calcium between children with vesicoureteral reflux and those with improved vesicoureteral reflux

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2011
Urinary reflux can cause irreversible complications such as reflux nephropathy and ESRD. Diagnostic imaging such as voiding cystourethrogram (VCUG) is invasive and causes irradiation.
Hamidreza Badeli   +4 more
doaj  

Venous Reflux on Contrast-Enhanced Head and Neck Magnetic Resonance Angiography: Analysis of Causative Factors

open access: yes대한영상의학회지, 2016
Purpose The purpose of this study was to analyze the causative factors of venous reflux on contrast-enhanced head and neck magnetic resonance angiography.
Dong Jae Shin, Eun Ja Lee, Jong Myon Bae
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

open access: yesAdvanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li   +12 more
wiley   +1 more source

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