Results 61 to 70 of about 19,567 (286)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Thermochemistry of MgCr2O4, MgAl2O4, MgFe2O4 spinels in SO2-O2-SO3 atmosphere [PDF]

Processing and Application of Ceramics, 2016
The present paper investigates high-temperature sulphate corrosion of basic refractory ceramics containing magnesium spinels (MgAl2O4, MgFe2O4, MgCr2O4 and their solid solutions) widely used in metallurgy, chemical, ceramic and glass industry. This group
Anna Gerle, Jerzy Piotrowski, Jacek Podwórny   +2 more
doaj   +1 more source

Signatures of rocky planet engulfment in HAT-P-4. Implications for chemical tagging studies

, 2017
Aims. To explore the possible chemical signature of planet formation in the binary system HAT-P-4, by studying abundance vs condensation temperature Tc trends. The star HAT-P-4 hosts a planet detected by transits while its stellar companion does not have
Arancibia, M. Jaque, Flores, M., Jofré, E., Martioli, E., Petrucci, R., Saffe, C.   +5 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Uso do resíduo de catalisador de processo de craqueamento catalítico fluído de hidrocarbonetos em refratários silicoaluminosos Use of catalyst waste from hydrocarbon fluid catalytic cracking process in alumina-silica refractories

Cerâmica, 2009
Este trabalho objetivou o desenvolvimento de metodologia para o aproveitamento do resíduo de catalisador de craqueamento de hidrocarbonetos, na produção de refratários silicoaluminosos.
L. P. Garcia, R. T. da Cruz, S. R. Bragança   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

New solar metallicity measurements

, 2019
In the past years, a systematic downward revision of the metallicity of the Sun has led to the "solar modeling problem", namely the disagreement between predictions of standard solar models and inferences from helioseismology.
Vagnozzi, Sunny
core   +1 more source

Chemical signatures of planets: beyond solar-twins [PDF]

, 2013
Elemental abundance studies of solar twin stars suggest that the solar chemical composition contains signatures of the formation of terrestrial planets in the solar system, namely small but significant depletions of the refractory elements.
Asplund, M., Melendez, J., Ramirez, I.
core   +3 more sources