Results 31 to 40 of about 585,126 (313)

Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02) : an open-label, phase 3 randomised controlled trial [PDF]

open access: yes, 2008
Background: Second-line chemotherapy for patients with oesophagogastric adenocarcinoma refractory to platinum and fluoropyrimidines has not shown benefits in health-related quality of life (HRQoL). We assessed whether the addition of docetaxel to active
Cliona C Kirwan (10530920)   +847 more
core   +1 more source

Stereotactic radiotherapy: An alternative option for refractory ventricular tachycardia to drug and ablation therapy [PDF]

open access: yes, 2022
Refractory ventricular tachycardia (VT) often occurs in the context of organic heart disease. It is associated with significantly high mortality and morbidity rates.
Shangguan, Wenfeng   +7 more
core   +1 more source

Maximizing the Utility of Transcriptomics Data in Inflammatory Skin Diseases

open access: yesFrontiers in Immunology, 2021
Inflammatory skin diseases are induced by disorders of the host defense system of the skin, which is composed of a barrier, innate and acquired immunity, as well as the cutaneous microbiome.
Jingni Wu   +5 more
doaj   +1 more source

Chronic migraine: treatability, refractoriness, pseudo-refractoriness [PDF]

open access: yesThe Journal of Headache and Pain, 2015
Chronic migraine (CM), a highly disabling condition affecting 2-3% of the general population, represents a difficult-to-treat disorder for its unclear pathophysiology, complex comorbidities, and disappointing response to available pharmacological treatments[1]. High quality evidence (≥2 RCTs) recommends the prophylactic use of onabotulinum toxin A (155-
Barbanti, Piero   +4 more
openaire   +2 more sources

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

open access: yes, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles   +15 more
core   +1 more source

Phase composition and strength of cement stone with a complex additive

open access: yesMATEC Web of Conferences, 2017
Ecologically friendly construction is impossible without the use of materials that are characterized by a low emission of dangerous substances from the surface and have other appropriate properties. A solution of the problem related to the elaboration of
Shabanova Galina   +2 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman   +7 more
wiley   +1 more source

Thermo-Insulating Moulding Sand for thin Walled Castings

open access: yesArchives of Metallurgy and Materials, 2014
In paper the selection of the composition and determination of main properties of novel moulding sand was described. The mail goal was to create moulding sand characterized by high thermal insulating properties in relations with low specific weight. This
Cholewa M., Szuter T.
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: The SPiRiT trial

open access: yes, 2008
Background: Patients with refractory angina have significant morbidity. This study aimed to compare two of the treatment options, Spinal Cord Stimulation (SCS) and Percutaneous Myocardial Laser Revascularisation (PMR) in terms of clinical outcomes and ...
Goldsmith KA   +40 more
core   +1 more source

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