Results 51 to 60 of about 585,126 (313)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Granulated refractory fillers for foundry production
Литьë и металлургия, 2000 By the specific chemical and phase compositions as well as the shape of grains close to spherical the refractory fillers can find application in foundry production as manufactured fillers.
V. V. Skurikhin +2 more
doaj
International Journal of Electrochemical Science, 2020 This work investigated the mechanism underlying the effect of polyoxyethylene ether (PEO-1100) on Zn nucleation and growth in a neutral solution (5 M NH4Cl).
Duoqiang Zhao +5 more
doaj +1 more source
Open Ceramics, 2023 The present work investigated the effect of relatively small additions of impurities originating in secondary raw materials on the thermomechanical properties of alumina castables bonded with active alumina.
Jacek Podwórny +8 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka +12 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The therapeutic targets and clinical translational research in vitiligo
生物医学转化Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, significantly impacting patients' quality of life. Recent advances in immunological and molecular biological studies have identified numerous potential therapeutic ...
Zhao Liuqi +6 more
doaj +1 more source
Current Opinion in Oncology, 2013 Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up.RCD has been subdivided into two subgroups according to the
Georgia, Malamut, Christophe, Cellier
openaire +5 more sources
Refractoriness and Neural Precision [PDF]
The Journal of Neuroscience, 1998 The response of a spiking neuron to a stimulus is often characterized by its time-varying firing rate, estimated from a histogram of spike times. If the cell’s firing probability in each small time interval depends only on this firing rate, one predicts a highly variable response to repeated trials, whereas many neurons show much greater fidelity ...
Michael J. Berry II, Markus Meister
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source