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Augmentation strategies in patients with refractory depression
In the evaluation of treatment-resistant or treatment-refractory depression (TRD), true resistance to antidepressant therapy must be distinguished from inadequate dose, duration, or compliance with past antidepressant therapy. Reassessment of the diagnosis may reveal psychiatric comorbidity, the presence of depressive subtypes, or the possibility of a ...
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Outcome in refractory depression
Failure to respond to first-line antidepressant treatment can occur in up to 40% of patients with depressive illness. A proven strategy for managing this refractory depression is lithium augmentation. The long-term outcome and optimal management of patients treated with lithium augmentation remains unclear. We describe a 4-8 year naturalistic follow-up
Shergill, S.S. +4 more
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Treatment of refractory depression
Depression and Anxiety, 1997Treatment of refractory depression is a common challenge for mental health professionals. To assure optimal treatment, the clinician should first determine that adequate dosage has been employed for an adequate duration. Next there are a variety of augmentation strategies or alternative antidepressants that could be considered.
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Stress Medicine, 1986
AbstractRefractory depression is a poorly defined illness involving the persistence of symptoms of major depression or dysthymia over a prolonged period of time despite attempts at medical and psychotherapeutic intervention. The authors present a review of literature relevant to defining, evaluating and treating refractory depression. Medical illnesses,
Mark Zetin +3 more
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AbstractRefractory depression is a poorly defined illness involving the persistence of symptoms of major depression or dysthymia over a prolonged period of time despite attempts at medical and psychotherapeutic intervention. The authors present a review of literature relevant to defining, evaluating and treating refractory depression. Medical illnesses,
Mark Zetin +3 more
openaire +1 more source
Buprenorphine Treatment of Refractory Depression
Journal of Clinical Psychopharmacology, 1995Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication.
J A, Bodkin +3 more
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Refractory depression in children and adolescents
Depression and Anxiety, 1997Refractory or treatments resistant depression in child and adolescent populations is a difficult construct to operationalize currently. To date, only one of the small number of completed double-blind placebo-controlled treatment investigations have not demonstrated a significant effect of antidepressants in comparison to placebo.
K N, Botteron, B, Geller
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Intravenous chlorimipramine and refractory depression
General Hospital Psychiatry, 1980A total of 252 infusions of chlorimipramine were performed on 12 patients with refractory depression. It is suggested that the intravenous route of administration is safe and effective. It may, in fact, be the preferred route when the oral route of administration is not available.
D L, Dudley, N, Volberding, P, Loebel
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Pharmacological Management of Refractory Depression
The Canadian Journal of Psychiatry, 1989Managing patients with “treatment resistant depression” offers a major challenge to clinical psychiatrists, psychopharmacologists, and others. Firstly, patient heterogeneity must be recognized in terms of symptom presentation, biological variables, co-morbidity with other psychiatric and medical disorders and associated personality disorder.
S H, Kennedy, R T, Joffe
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Novel Antidepressant Approaches for Refractory Depression
Current Treatment Options in Psychiatry, 2021Purpose of Review: Although monoaminergic antidepressants are effective for some depressed patients, at least a third remain treatment refractory even after multiple treatment trials. Investigation into novel antidepressant approaches targeted to specific mechanisms implicated in the pathophysiology of treatment-resistant depression (TRD) has ...
Postorivo, Danielle, Tye, Susannah J.
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