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Treatment of refractory bipolar depression
Current Psychiatry Reports, 2007Methods: This multicenter study used a randomized but open-label design. Study drugs (tranylcypromine, 20–100 mg/d, or lamotrigine, 25–400 mg/d) were added to ongoing therapy with a mood stabilizer (lithium, valproate, or carbamazepine at therapeutic levels). The trial’s first stage lasted 10 weeks.
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Role of Ketamine in Refractory Depression
Telangana Journal of IMA, 2021Context: Refractory depression is seen in at least 10 to 30 percent of the patients suffering from depression. Ketamine is a new and effective option with rapid onset of action. But there are limited studies where IM Ketamine was used for treating refractory depression.
Kolluri Maithri +2 more
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Adjunctive yohimbine for treatment in refractory depression
Biological Psychiatry, 1993Most antidepressant drugs, as well as electroconvulsive therapy (ECT), exert clinical efficacy over a time period corresponding to the drug's effect of decreasing the density of postsynaptic beta-adrenergic receptors in the brain (Sulser 1984). This finding has led to the hypothesis that "down-regulation" of postsynaptic beta receptors may be one of ...
M H, Pollack, P, Hammerness
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Clozapine in the Treatment of Psychotic Refractory Depression
British Journal of Psychiatry, 1993A 40-year-old woman suffering from major depression with psychotic features was unresponsive to conventional therapy. After the administration of a wide range of drug treatments and ECT, she received clozapine. Depressive symptoms improved and psychotic features disappeared.
D, Dassa +3 more
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Treatment-Refractory Depression
2004Despite the availability of many newer antidepressant medications, a significant percentage of patients are partial responders or have treatment-resistant depression (TRD). In such cases, there are very few data to indicate what step (combination, augmentation, or switching) should be taken next.
M. Trivedi, T. Bettinger, B. Kleiber
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Bupropion/Nortriptyline Combination for Refractory Depression
Annals of Clinical Psychiatry, 1994Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant ...
J T, Apter, S F, Kushner, R L, Woolfolk
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Treatment-refractory depression: Definitions and characteristics
Depression and Anxiety, 1997Forty to 50% of depressed patients who are initially prescribed antidepressant medications or administered electroconvulsive therapy do not experience a timely remission. This group typifies treatment-refractory depression (TRD), defined as a failure to demonstrate an "adequate" response to an "adequate" treatment trial (i.e., sufficient intensity of ...
R M, Berman, M, Narasimhan, D S, Charney
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Efficacy of fluvoxamine in treatment-refractory depression
Journal of Affective Disorders, 1988The efficacy of the potent and selective unicyclic serotonin reuptake inhibitor, fluvoxamine, was evaluated in 38 consecutively admitted depressed patients judged refractory to standard antidepressants using operationalized criteria. Twenty-eight patients completed a single-blind protocol involving greater than or equal to 2 weeks of placebo and 4-6 ...
P L, Delgado +3 more
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Mirtazapine Augmentation in the Treatment of Refractory Depression
The Journal of Clinical Psychiatry, 1999Pharmacotherapeutic strategies that target specific actions at multiple neuronal receptors or cellular components may offer a superior approach for treatment of refractory depression. Mirtazapine is a novel antidepressant which has a mechanism that involves the enhancement of noradrenergic and serotonergic neurotransmission via blockade of alpha2 ...
L L, Carpenter +4 more
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Psychotherapy of refractory depressions
Depression and Anxiety, 1997Psychotherapy is a potentially valuable intervention for treatment-resistant depression. This review provides a brief, general overview of the use of psychotherapy to treat depression and more focused consideration of time-limited interpersonal, behavioral, and cognitive behavioral strategies for patients who are not responsive to antidepressant ...
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