Results 131 to 140 of about 356,945 (257)

Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy. [PDF]

Neurol Med Chir (Tokyo)
Ujihara M, Kawabori M, Nakajima M, Ueda Y, Horinouchi T, Egawa K, Kato TA, Fujimura M.   +7 more
europepmc   +1 more source

What is Refractory Epilepsy?

, 2003
RESUMEN: Se discute la epilepsia refractaria contemplando sus aspectos biológicos, farmacológicos y psicosociales. Entre los primeros se consideran los avances recientes de fisiopatología, inmunología y genética que pueden producir epilepsia refractaria.
Cornejo Ochoa, José William, Carrizosa Moog, Jaime   +1 more
core  

Cost‐effectiveness of laser interstitial thermal therapy vs. anterior temporal lobectomy for drug‐resistant mesial temporal lobe epilepsy: A decision analytic model

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the comparative cost‐effectiveness of anterior temporal lobectomy (ATL) and magnetic resonance–guided laser interstitial thermal therapy (LITT) in patients with drug‐resistant mesial temporal lobe epilepsy (mTLE). Methods A decision‐analytic model was constructed to simulate the risks, benefits, and costs of ATL versus ...
Zhihao Guo, Yihe Wang, Kailiang Wang, Yongzhi Shan, Guoguang Zhao   +4 more
wiley   +1 more source

cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy. [PDF]

Nat Neurosci
Huang Y, Fan L, Wong MY, Lei Z, Krishnamachary B, Zhu D, Cadiz MP, Nagiri RK, Ye P, Norman K, Bhagwat M, Lee YJ, Li H, Zhu J, Amin S, Lauderdale K, Chen H, Luo W, Gong S, Liechty BL, Palop JJ, Sinha SC, Wu J, Zhao M, Gan L.   +24 more
europepmc   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

KCNJ4 variants disrupt inward-rectifier potassium channel function and cause refractory epilepsy. [PDF]

Epilepsia
Pan H, Liu D, Xu W, Li Y, Hu J, Henry O, Fuchs A, Jamra RA, Liu Z, He M, Chen Y, Wu S, Dong X, Chen Y, Wang P, Gu W, Jing H, Tang Y, Wang YJ, Mao X, Xiao N.   +20 more
europepmc   +1 more source

Efficacy of stiripentol, fenfluramine, and their combination on clinical outcomes in Dravet syndrome: A preliminary report

Epilepsia Open, EarlyView.
Abstract Objective Stiripentol and fenfluramine are approved treatments for Dravet syndrome (DS), but real‐world data comparing their effectiveness and combined use remain limited. Our study aims to explore associations between treatment with stiripentol, fenfluramine, and their combination and clinical outcomes in patients with DS.
Paolo Surdi, Marina Trivisano, Mattia Mercier, Nicola Pietrafusa, Angela De Dominicis, Costanza Calabrese, Simona Cappelletti, Nicola Specchio   +7 more
wiley   +1 more source

Assessment of the utility of optically pumped magnetometer magnetoencephalography in preoperative localization of refractory epilepsy: A prospective study. [PDF]

Epilepsia
Shen Y, You C, Zhang Y, Ji N, Zhao X, Zhang P, Huang S, Kang H, Liu X, Peng Y, Sun C, Yan B, Zhang Y, Zhu S, Zhu W, Lei T, Tang Z, Ding M, Hu F, Shu K.   +19 more
europepmc   +1 more source

Transcutaneous auricular vagus nerve stimulation in drug‐resistant epilepsy: A randomized, sham‐controlled crossover trial with exploratory EEG and MRI response phenotyping

Epilepsia Open, EarlyView.
Abstract Objective Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive neuromodulation strategy for drug‐resistant epilepsy, but clinical response is heterogeneous. We examined whether electroencephalographic (EEG) and structural magnetic resonance imaging (MRI) phenotypes were associated with active‐specific clinical benefit from
Sung Jun Hong, Seok‐Yeol Yang, Eun Kyung Bok, Jung Chul Lee, Yeonggin Kim, Kyousik Min, Young‐Min Shon   +6 more
wiley   +1 more source

Ketogenic Diet Versus Immunological Therapy in the Management of Refractory Epilepsy in Children. [PDF]

Cureus
Elasheer OM, Eldaly EH, Gad EF, Elgalaly NA, Raafat DM, ElGyar N.   +5 more
europepmc   +1 more source