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Surgical treatment for refractory epilepsy
Journal of Neurosurgical Sciences, 2018The goal of any epilepsy surgery is to improve patient's quality of life by achieving seizure freedom or by reducing the frequency of severely debilitating seizures. To achieve this goal, non-invasive and invasive diagnostic methods must precisely delineate the epileptogenic zone (EZ), which is defined as the area that needs to be resected to obtain ...
Johannes, Herta, Christian, Dorfer
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Thalidomide for treatment of refractory epilepsy
Epilepsy Research, 2010We have experimentally shown that thalidomide has strong anticonvulsant properties. In an open label study, eight male patients with refractory epilepsy received thalidomide at daily-doses of 200 mg during 1 year, frequency of seizures before and during treatment were compared.
Guadalupe, Palencia +4 more
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Refractory epilepsy: mechanisms and solutions
Expert Review of Neurotherapeutics, 2006Pharmacoresistance remains a major challenge in epilepsy management. The availability of ten new antiepileptic drugs since the late 1980s has not dramatically improved the outcome of refractory epilepsy. This article provides an overview of the contemporary understanding of epilepsy and the limitation of current treatment modalities, discusses putative
Patrick, Kwan, Martin J, Brodie
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Etiology and management of refractory epilepsies
Nature Clinical Practice Neurology, 2007The epilepsies are an important, common and diverse group of symptom complexes characterized by recurrent spontaneous seizures. Although many patients with epilepsy have their seizures controlled effectively by antiepileptic drugs (AEDs), about one-third of patients continue to have seizures, despite trying a range of AEDs.
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Refractory epilepsy in a Chinese population
Clinical Neurology and Neurosurgery, 2007To investigate the proportion of Chinese patients with intractable seizures and the risk factors leading to refractory epilepsy.Consecutive patients over 14 years of age attending a Neurology clinic were evaluated. Patients with epilepsy were classified into two groups according to their seizure control: refractory or seizure-free.
Andrew C F, Hui +5 more
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Felbamate in refractory partial epilepsy
Epilepsy Research, 1999This open-label study was performed to evaluate efficacy and safety of Felbamate (FBM) add-on therapy in drug-refractory partial epilepsy. We evaluated 36 patients (12 males) aged 11-68 years (mean 29.8) in which FBM was titrated gradually from 300 mg/day to a mean total maintenance daily dose of 1936 mg.
R. Canger +3 more
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The Journal of the Association of Physicians of India, 2014
Refractory Epilepsy (R.E.) is a condition where all antiepileptic drugs (AEDs) fail to provide adequate seizure control. To diagnose R.E., false cases of refractoriness need to be carefully excluded. There are several predictors of refractoriness. The treatment options in R.E. are resective surgery, ketogenic diet and vagal nerve stimulation. The roles
Tapas Kumar, Banerjee +1 more
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Refractory Epilepsy (R.E.) is a condition where all antiepileptic drugs (AEDs) fail to provide adequate seizure control. To diagnose R.E., false cases of refractoriness need to be carefully excluded. There are several predictors of refractoriness. The treatment options in R.E. are resective surgery, ketogenic diet and vagal nerve stimulation. The roles
Tapas Kumar, Banerjee +1 more
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Diagnosing and predicting refractory epilepsy
Acta Neurologica Scandinavica, 2005Over 30% of people with epilepsy will never achieve remission with antiepileptic drug (AED) therapy. These individuals are often severely disabled by their condition, have an unsatisfactory quality of life, and are at increased risk of sudden unexpected death.
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Revista paulista de medicina, 1991
To describe the role of multidisciplinary evaluation and general aspects of intractable epilepsies such as age at the onset, etiologic factors, CT scan findings, electroencephalographic abnormalities, types of epileptic seizures, adherence, and crisis-triggering factors.Retrospective.
M, de Albuquerque +3 more
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To describe the role of multidisciplinary evaluation and general aspects of intractable epilepsies such as age at the onset, etiologic factors, CT scan findings, electroencephalographic abnormalities, types of epileptic seizures, adherence, and crisis-triggering factors.Retrospective.
M, de Albuquerque +3 more
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Intensive monitoring in refractory epilepsy
Neurology, 1981Forty patients with intractable seizures were studied in an epilepsy unit for an average of 8 weeks with video-electroencephalographic telemetry and continuous observation by trained personnel. Drugs were administered on the basis of antiepileptic drug measurements and seizure classification determined by clinical observation and telemetry.
T P, Sutula +3 more
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