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Refractory status epilepticus is a potentially life-threatening medical emergency. It requires early diagnosis and treatment. There is a lack of consensus upon its semantic definition of whether it is status epilepticus that continues despite treatment ...
Sanjay P Singh +2 more
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Updates in Refractory Status Epilepticus [PDF]
Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic etiology as the
Rohit Marawar +5 more
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Status epilepticus (SE) is a neurological emergency with a high mortality rate. When compared to chronic epilepsy, it is distinguished by the durability of seizures and frequent resistance to benzodiazepine (BZD).
Tzu-Hsin Huang +3 more
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Refractory and Super-refractory Status Epilepticus [PDF]
Refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) are neurological emergencies with considerable mortality and morbidity. In this paper, we provide an overview of causes, evaluation, treatment, and consequences of RSE and SRSE, reflecting the lack of high-quality evidence to inform therapeutic approach.This is a ...
Samanta, Debopam +2 more
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Status Epilepticus and Refractory Status Epilepticus Management [PDF]
Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically,
Nicholas S, Abend +7 more
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Stiripentol in refractory status epilepticus [PDF]
SummaryBenzodiazepines (BZDs), which enhance γ‐aminobutyric acid (GABAA) receptor–mediated inhibition, are the first‐line therapy for treatment of status epilepticus (SE). However, pharmacoresistance toBZDs develops rapidly afterSEinitiation. This is due to an activity‐dependent internalization ofBZD‐sensitiveGABAAreceptors duringSE.
Denise K, Grosenbaugh, David D, Mott
openaire +2 more sources
Super-refractory status epilepticus and pharmacoresistant epilepsy in an infant with hemorrhagic shock and encephalopathy syndrome [PDF]
Introduction. Hemorrhagic shock and encephalopathy syndrome (HSES) is a rare disorder with prevalence at an early age. The main features of HSES are acute diarrhea, shock, disseminated intravascular coagulation, multisystem impairment, and encephalopathy.
Kravljanac Ružica +3 more
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A Study of Super Refractory Status Epilepticus from India
BackgroundSuper refractory status epilepticus (SRSE) is an important and recently recognized neurological emergency.PurposeIn view of paucity of studies on SRSE, we report the frequency, etiology and outcome of SRSE.MethodsIn a hospital-based ...
Usha K. Misra +2 more
doaj +1 more source
Introduction. Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an
Christopher R. Newey +4 more
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Purpose: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAr encephalitis) is an auto-immune disorder associated with the production of antibodies against NR1 and NR2 sub units of the NMDA receptor.
Jonathan D. Santoro, MD +2 more
doaj +1 more source

