Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
An NHC‐Coordinated Silicon/Sulfur Analogue of an Acyl Carbene
Angewandte Chemie, EarlyView.An NHC complex of an Si/S analogue of an acyl carbene is synthesized by the reaction of a disilyne with a cyclic thiourea. The observed Si2S three‐membered ring with unsymmetrical Si─S distances and a Si─Si single bond is consistent with intramolecular coordination of the silathioacyl sulfur to the silylene center.
Takuto Toyooka +2 more
wiley +2 more sources
Study on a Fault Diagnosis Method for Heterogeneous Chiller Units Based on Transfer Learning. [PDF]
Entropy (Basel)Feng Q +6 more
europepmc +1 more source
Decommissioning and Safe Disposal of Vaccine Cold Chain Equipment in Low- and Middle-Income Countries: Focusing on Processes, Risks, and Practical Challenges. [PDF]
CureusSingh SK +8 more
europepmc +1 more source
Highly ordered rubbers with a giant elastocaloric effect. [PDF]
Sci AdvFu Y +14 more
europepmc +1 more source
Experimental investigation of Fe<sub>3</sub>O<sub>4</sub> nano-oil and outdoor temperature effects on a 5-ton R22 vapor compression chiller performance. [PDF]
Sci RepMohseni M, Fathollahi AH.
europepmc +1 more source
A novel ultra-low temperature cascade refrigeration with dual auxiliary loop to enhance thermal performance. [PDF]
Sci RepKumar S, Gahlot P, Kumar S, Kumar A.
europepmc +1 more source
Selective defluorination of 1,1,1,2-tetrafluoroethane by lithium phosphide reagents.
Dalton TransWarsame HR, Demetriou CM, Crimmin MR.
europepmc +1 more source