Results 121 to 130 of about 28,422 (241)
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Climate-friendly technologies in the mobile air-conditioning sector: A patent citation analysis [PDF]
The development of climate-friendly technologies and its diffusion across countries is of key importance to slow climate change. This paper considers technologies in the mobile air-conditioning (MAC) sector which is a major contributor of ...
Frank Goetzke, Tilmann Rave
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Engineering design project : series 2 [PDF]
, 2017 This book is a compilation of engineering design projects which illustrates a detail explanation on the design process including all tools and methods involved in each design stage.
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Advanced Science, EarlyView.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
Advanced Science, EarlyView.We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang +14 more
wiley +1 more source
Characterization of Two-Phase Flow in Microchannels [PDF]
, 2002 Aluminum multi-port microchannel tubes are currently utilized in automotive air conditioners for refrigerant condensation. Recent research activities are directed toward developing other air conditioning and refrigeration systems with microchannel ...
Hrnjak, P.S., Newell, T.A., Nino, V.G.
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Advanced Science, EarlyView.In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei +17 more
wiley +1 more source
Exergy, Performance And Environmental Impact Analysis Of Compression Refrigeration Systems [PDF]
, 2014 Major concern in refrigeration hinges largely on energy conservation, environmental safety and efficient cooling system. The concept of quality of useful energy which invariably leads to energy conservation is naturally related to exergy.
Adelekan, D.S +3 more
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Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics
Advanced Science, EarlyView.. ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao +3 more
wiley +1 more source
Evaluation of absorption cycle for space station environmental control system application Interim report [PDF]
Zero-gravity absorption refrigeration system design and performance testing for space station environmental control ...
Hale, D. V., Liu, C. K., Thoenes, J.
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