Results 51 to 60 of about 7,958 (196)

Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40

Neurobiology of Disease, 2011
The accumulation of the two branched-chain fatty acids phytanic acid and pristanic acid is known to play an important role in several diseases with peroxisomal impairment, like Refsum disease, Zellweger syndrome and α-methylacyl-CoA racemase deficiency ...
Nicol Kruska, Georg Reiser
doaj   +1 more source

Relationship Between Physical Conditioning and Plasma High Density Lipoprotein-Cholesterol Concentration [PDF]

, 1983
Five subjects (three females and two males) took part in an exercise regimen in order to determine if aerobic exercise results in an increase in high-density lipoprotein-cholesterol levels (HDL-C) in the plasma.
Baeyens, Dennis A., Morgans, Leland F., Morris, Manford D.   +2 more
core   +2 more sources

Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. [PDF]

, 2005
BACKGROUND: Atherosclerosis develops from childhood, but the determinants of this preclinical stage remain uncertain. We examined the relations of classic coronary risk factors, adiposity and its associated metabolic disturbances, to arterial ...
Cook, DG, Deanfield, JE, Donald, AE, Gilg, JA, Katterhorn, M, Oliver, C, Whincup, PH   +6 more
core   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

Journal of Lipid Research, 1997
Peroxisomal disorders arise either from defects in the biogenesis of peroxisomes or from the defective synthesis of one or more peroxisomal enzymes. These defects result in metabolic disturbances in peroxisomal beta-oxidation of various fatty acids and ...
Y Y van der Hoek, R J Wanders, A E van den Ende, H G Kraft, B R Gabel, J J Kastelein, M L Koschinsky   +6 more
doaj   +1 more source

Hyperhomocysteinemia - An unidentified risk factor for stroke in our population [PDF]

, 2015
Introduction: Various studies show that moderate elevation of plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease.
Alvi, Shafaq, Asif, Sabaa, Sartaj, Kanwal, Soomro, Bashir A   +3 more
core   +1 more source

Homocysteine concentrations in the cognitive progression of Alzheimer’s disease [PDF]

, 2017
Objectives: Hyperhomocysteinemia in Alzheimer’s disease (AD) is widely reported and appears to worsen as the disease progresses. While active dietary intervention with vitamins B12 and folate decreases homocysteine blood levels, with promising clinical ...
Farina, Nicolas, Hart, Kathryn, Jernerén, Fredrik, Tabet, Naji, Turner, Cheryl   +4 more
core   +2 more sources

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, Volume 603, Issue 22, Page 6949-6977, November 15, 2025.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

Phytanic acid oxidation: normal activation and transport yet defective alpha-hydroxylation of phytanic acid in peroxisomes from Refsum disease and rhizomelic chondrodysplasia punctata

Journal of Lipid Research, 1996
In humans the oxidation of phytanic acid is a peroxisomal function. To understand the possible mechanisms for the pathognomic accumulation of phytanic acid in plasma and body fluids of Refsum disease (RD) and rhizomelic chondrodysplasia punctata (RCDP ...
K Pahan, M Khan, I Singh
doaj   +1 more source

Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia [PDF]

, 2009
Background Homocysteine levels in circulation are determined by several factors and hyperhomocysteinemia is reportedly associated with cardiovascular diseases and dementia. The aim of this study is to determine the relation of chronic gastritis and other
Stefan Redéen, Anna Ryberg, Fredrik Petersson, Olle Eriksson, Katarina Nägga, Kurt Borch, J Selhub, P Frosst, K Prasad, K Nilsson, M Soinio, H Evrengul, C Guldener van, E Randers, MR Nehler, DS Wald, S Seshadri, B Hultberg, DG Bloemenkamp, ES Ford, H Refsum, S Saibeni, W Dickey, O Shuval-Sudai, A Tamura, J Danesh, K Borch, K Borch, MF Dixon, J Alexander, YQ Sun, L Fratiglioni, B Ozer, N Salles-Montaudon, IJ Kullo, P Sipponen, N Ilhan, SJ Lewis, H Refsum, L Santarelli, WK Leung, NJ Wald, E Arnesen, CD Stehouwer, ML Bots, Homocysteine Studies Collaboration., PH Whincup, UB Fallon, G Ravaglia   +48 more
core   +1 more source