Results 11 to 20 of about 389 (131)
Simulated model of RAPID concept: highlighting innate inflammation and liver regeneration. [PDF]
BJS Open, 2020 The mechanism of RAPID‐associated liver regeneration and its regulation remains unclear. A RAPID model in rats was developed involving cold ischaemia and reperfusion of the selected future liver remnant, portal vein ligation of the remaining segments during step I, and resection of the deportalized lobes during step II.
Shi JH, Yan X, Zhang SJ, Line PD.
europepmc +2 more sources
Commonalities and differences in carotid body dysfunction in hypertension and heart failure
The Journal of Physiology, Volume 601, Issue 24, Page 5527-5551, 15 December 2023., 2023 Abstract figure legend The carotid body has been linked with the development of hypertension and heart failure in animals and humans. This review explores mechanisms of carotid body sensitisation across disease models. We ask whether these mechanisms are common or unique to distinct cardiovascular diseases; such knowledge could inform clinical ...
Igor S. A. Felippe +4 more
wiley +1 more source
Stem Cells International, Volume 2022, Issue 1, 2022., 2022 Endodontics has made significant progress in regenerative approaches in recent years, thanks to advances in biologically based procedures or regenerative endodontic therapy (RET). In recent years, our profession has witnessed a clear conceptual shift in this therapy.
C. Brizuela +5 more
wiley +1 more source
Retinoic acid increases phagocytosis of myelin by macrophages
Journal of Cellular Physiology, Volume 236, Issue 5, Page 3929-3945, May 2021., 2021 We have investigated whether ligands of nuclear receptor families retinoic acid receptors, retinoid X receptors, peroxisome proliferator‐activated receptors, lipid X receptors, and farnesoid X receptors increase myelin phagocytosis by murine bone marrow–derived macrophages and Raw264.7 cells.
Siyu Wu +2 more
wiley +1 more source
Hepatology, Volume 73, Issue 2, Page 606-624, February 2021., 2021 Background and Aims G protein–coupled receptor (GPR) 55 is a putative cannabinoid receptor, and l‐α‐lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of nonalcoholic ...
Marcos F. Fondevila +33 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta‐peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. Interestingly, it has been reported that oxidative stress can
Pol Picón-Pagès +12 more
wiley +1 more source
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
Neural Plasticity, Volume 2017, Issue 1, 2017., 2017 Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time
Viviana I. Torres +3 more
wiley +1 more source
The Gαo Activator Mastoparan‐7 Promotes Dendritic Spine Formation in Hippocampal Neurons
Neural Plasticity, Volume 2016, Issue 1, 2016., 2016 Mastoparan‐7 (Mas‐7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX‐) sensitive G proteins. Mas‐7 produces several biological effects in different cell types; however, little is known about how Mas‐7 influences mature hippocampal neurons. We examined the specific role of Mas‐7 in
Valerie T. Ramírez +3 more
wiley +1 more source
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
Neural Plasticity, Volume 2015, Issue 1, 2015., 2015 Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti‐inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase‐3β (GSK‐3β), a key enzyme of the Wnt/β‐catenin signaling cascade. Since this signaling pathway regulates neurogenesis in the
Lorena Varela-Nallar +5 more
wiley +1 more source
Oxidative Stress in Aging: Advances in Proteomic Approaches
Oxidative Medicine and Cellular Longevity, Volume 2014, Issue 1, 2014., 2014 Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism itself deteriorate in a progressive and irreversible manner that, in the majority of cases, implies pathological conditions that affect the individual’s Quality of Life (QOL).
Daniel Ortuño-Sahagún +3 more
wiley +1 more source