Results 1 to 10 of about 1,340,212 (344)

CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

Human Genomics, 2023
Background Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) appearing in non-coding genomic regions in CVDs.
Chaonan Zhu, Nina Baumgarten, Meiqian Wu, Yue Wang, Arka Provo Das, Jaskiran Kaur, Fatemeh Behjati Ardakani, Thanh Thuy Duong, Minh Duc Pham, Maria Duda, Stefanie Dimmeler, Ting Yuan, Marcel H. Schulz, Jaya Krishnan   +13 more
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The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells

Cell Death and Disease, 2021
Resistin-like alpha (Retnla) is a member of the resistin family and known to modulate fibrosis and inflammation. Here, we investigated the role of Retnla in the cardiac injury model.
Yong Sook Kim, Hyang Hee Cho, Dong Im Cho, Hye-yun Jeong, Soo yeon Lim, Ju Hee Jun, Mi Ra Kim, Bo Gyeong Kang, Meeyoung Cho, Hye-jin Kang, Wan Seok Kang, Goo Taeg Oh, Youngkeun Ahn   +12 more
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Differential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging

Scientific Reports, 2021
Knee cartilage is in an aqueous environment filled with synovial fluid consisting of water, various nutrients, and ions to maintain chondrocyte homeostasis.
Bong Soo Kyung, Koo Whang Jung, Woo Jin Yeo, Hye Kyung Seo, Yong-Soo Lee, Dong Won Suh   +5 more
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Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Communications Biology, 2023
Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to the improvement of adult neurogenesis, while leaving the possible circuitry mechanism unclear.
Zhihua Luo, Junlin Chen, Yelin Dai, Kwok-Fai So, Li Zhang   +4 more
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Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur

Bioengineering, 2023
The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca, Andrea Wagner, Bettina Faustini, Nadja Weissenbacher, Christian Deininger, Florian Wichlas, Herbert Tempfer, Ernst J. Mueller, Andreas Traweger   +8 more
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Physical exercise mediates a cortical FMRP–mTOR pathway to improve resilience against chronic stress in adolescent mice

Translational Psychiatry, 2023
Aerobic exercise effectively relieves anxiety disorders via modulating neurogenesis and neural activity. The molecular mechanism of exercise-mediated anxiolysis, however, remains incomplete. On a chronic restrain stress (CRS) model in adolescent mice, we
Lan Yan, Mei Wang, Fengzhen Yang, Yajie Wang, Siqi Wang, Kwok-Fai So, Li Zhang   +6 more
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Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Stem Cell Research & Therapy, 2022
Background Anti-angiogenic therapy has been shown to be a promising strategy for anti-tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by exosomes that are secreted by mesenchymal stem cells (MSCs), but whether exosomes ...
Panpan Liu, Qun Zhang, Jun Mi, Shuangshuang Wang, Qiuping Xu, Dexuan Zhuang, Wenqian Chen, Chang Liu, Liwei Zhang, Jing Guo, Xunwei Wu   +10 more
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Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Journal of Biomedical Science, 2017
Background Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration.
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng   +14 more
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Parental perspectives long term after neonatal clinical trial participation: a survey

Trials, 2020
Background Although recruiting newborns is ethically challenging, clinical trials remain essential to improve neonatal care. There is a lack of empirical data on the parental perspectives following participation of their neonate in a clinical trial ...
Thomas Salaets, Emilie Lavrysen, Anne Smits, Sophie Vanhaesebrouck, Maissa Rayyan, Els Ortibus, Jaan Toelen, Laurence Claes, Karel Allegaert   +8 more
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Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment

Stem Cells International, 2022
Background. Angiogenic tissue engineering is a vital problem waiting to be settled for periodontal regeneration. Erythropoietin, a multieffect cytokine, has been reported as a protective factor for cell fate.
Denghao Huang, Jie Lei, Xingrui Li, Zhonghao Jiang, Maoxuan Luo, Yao Xiao   +5 more
doaj   +1 more source