Results 41 to 50 of about 1,456,885 (313)

Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

open access: yesStem Cell Research & Therapy, 2022
Background Anti-angiogenic therapy has been shown to be a promising strategy for anti-tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by exosomes that are secreted by mesenchymal stem cells (MSCs), but whether exosomes ...
Panpan Liu   +10 more
doaj   +1 more source

HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]

open access: yes, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini   +5 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Heroism

open access: yesRegeneration
A multimodal collaboration between artists, writers, and scholars. This piece emerged from an expedition to the Arctic archipelago as part of the Arctic Circle Residency in Autumn 2022.
Andrea Legge   +3 more
doaj   +2 more sources

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

open access: yesNature Communications, 2018
LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-
Philipp Neumann   +11 more
doaj   +1 more source

Chalk and Cheese: A comparison of England and Scotland’s emerging approaches to regeneration [PDF]

open access: yes, 2012
To suggest that the Department for Communities and Local Government’s (DCLG’s) publication Regeneration to Enable Growth: What Government Is Doing in Support of Community-Led Regeneration, issued in early 2011, was a disappointment to many is something ...
Errington, Barry   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Unalienating Carbon: Affect and Labour in Artisanal Carbon Removal Work

open access: yesRegeneration
Carbon is rapidly undergoing a joint technological and cultural transformation. With the prolific rise of carbon dioxide removal in the climate pathways and net zero commitments that contour wider energy transitions, carbon emissions are increasingly ...
Anne Pasek
doaj   +2 more sources

Hallmarks of regeneration

open access: yesCell Stem Cell
Regeneration is a heroic biological process that restores tissue architecture and function in the face of day-to-day cell loss or the aftershock of injury. Capacities and mechanisms for regeneration can vary widely among species, organs, and injury contexts.
Poss, Kenneth D., Tanaka, Elly M.
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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