Results 51 to 60 of about 2,200,062 (357)

Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes

Scientific Reports, 2017
Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes.
Ece Öztürk, Stefanie Hobiger, Evelin Despot-Slade, Michael Pichler, Marcy Zenobi-Wong   +4 more
doaj   +1 more source

Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Stem Cell Research & Therapy, 2022
Background Anti-angiogenic therapy has been shown to be a promising strategy for anti-tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by exosomes that are secreted by mesenchymal stem cells (MSCs), but whether exosomes ...
Panpan Liu, Qun Zhang, Jun Mi, Shuangshuang Wang, Qiuping Xu, Dexuan Zhuang, Wenqian Chen, Chang Liu, Liwei Zhang, Jing Guo, Xunwei Wu   +10 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Globalizing Diné (Navajo) Stories of Radioactive Injustice: Transnational and Settler Colonial Politics of Uranium Mining in the Late 1970s and Early 1980s

Regeneration
The traumatic impacts of uranium mining on Diné (Navajo) communities in Arizona, New Mexico, and Utah in the late 20th century – from high cancer rates among mineworkers and their families to the radioactive contamination of local resources &
Jacob Tropp
doaj   +2 more sources

Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment

Stem Cells International, 2022
Background. Angiogenic tissue engineering is a vital problem waiting to be settled for periodontal regeneration. Erythropoietin, a multieffect cytokine, has been reported as a protective factor for cell fate.
Denghao Huang, Jie Lei, Xingrui Li, Zhonghao Jiang, Maoxuan Luo, Yao Xiao   +5 more
doaj   +1 more source

Experimental and theoretical research on the electrical conductivity of a liquid desiccant for the liquid desiccant air-conditioning system: LiCl aqueous solution [PDF]

, 2018
At present, the energy consumption in buildings occupies a large proportion of total energy use, and air-conditionings cost a large proportion of energy in the buildings. The liquid desiccant air-conditioning system has a good energy saving potential and
Cheng, Q, Feng, W, Wang, H, Xu, W
core   +1 more source

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Cell Metabolism, 2020
Summary Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and ...
Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, R. Gianni-Barrera, Evi Masschelein, G. D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, Tongtong Wang, M. Planque, P. Carmeliet, L. Pellerin, C. Wolfrum, S. Fendt, A. Banfi, C. Stockmann, Ines Soro-Arnaiz, M. Kopf, Katrien de Bock   +20 more
semanticscholar   +1 more source

New Insights Into Tissue Culture Plant-Regeneration Mechanisms

Frontiers in Plant Science, 2022
Plant regeneration occurs when plants repair or replace damaged structures based on the totipotency and pluripotency of their cells. Tissue culture is one of the most widely used regenerative technologies. Recently, a series of breakthroughs were made in
Y. Long, Yun Yang, G. Pan, Yaou Shen
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Unalienating Carbon: Affect and Labour in Artisanal Carbon Removal Work

Regeneration
Carbon is rapidly undergoing a joint technological and cultural transformation. With the prolific rise of carbon dioxide removal in the climate pathways and net zero commitments that contour wider energy transitions, carbon emissions are increasingly ...
Anne Pasek
doaj   +2 more sources