Results 71 to 80 of about 1,456,885 (313)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A critical analysis of urban regeneration programmes in Europe [PDF]
, 2015 Urban regeneration is informed and driven by the causes and effects of globalization, climate change, the global economic crisis, and lifestyle changes.
Durosaiye, Isaiah Oluremi, Hadjri, Karim
core
Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. [PDF]
, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
CHISHOLM, Andrew, Tang, Ngang
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Communications BiologyThe accumulation of α-synuclein induces neuronal loss in midbrain nuclei and leads to the disruption of motor circuits, while the pathology of α-synuclein in cortical regions remains elusive.
Borui Zhang +8 more
doaj +1 more source
Adjuvant role of macrophages in stem cell-induced cardiac repair in rats
Experimental and Molecular Medicine, 2018 Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing
Soo yeon Lim +7 more
doaj +1 more source
Parental perspectives long term after neonatal clinical trial participation: a survey
Trials, 2020 Background Although recruiting newborns is ethically challenging, clinical trials remain essential to improve neonatal care. There is a lack of empirical data on the parental perspectives following participation of their neonate in a clinical trial ...
Thomas Salaets +8 more
doaj +1 more source
ENVIRONMENTAL VARIABLES ASSOCIATED WITH INVASIVE GLOSSY BUCKTHORN (FRANGULA ALNUS MILL.) AND INDIRECT CONTROL STRATEGIES FOR FOREST MANAGERS [PDF]
, 2016 Glossy buckthorn (Frangula alnus Mill.) is one of the most prominent non-native invasive plant species affecting New England forests. It quickly invades a forest and can create a dense understory effectively altering the species composition and dynamics
KOZIKOWSKI, JOSHUA GLIDDEN
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Quantum Bit Regeneration [PDF]
, 1996 Decoherence and loss will limit the practicality of quantum cryptography and computing unless successful error correction techniques are developed. To this end, we have discovered a new scheme for perfectly detecting and rejecting the error caused by ...
A. Imamoglu +17 more
core +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source