TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling [PDF]
, 2018 Preconditioning nerve injuries activate a pro-regenerative program that enhances axon regeneration for most classes of sensory neurons. However, nociceptive sensory neurons and central nervous system neurons regenerate poorly.
DiAntonio, Aaron +4 more
core +2 more sources
, 2012 The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact.
Wen-Yee, Choi, Kenneth D, Poss
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A reliable system for the transformation of cantaloupe charentais melon (Cucumis melo L. var. cantalupensis) leading to a majority of diploid regenerants [PDF]
, 2000 An efficient system of transformation leading to a majority of transformed diploid plants from leaf explants of Cucumis melo L. var. Cantalupensis (cv. Védrantais) was developed.
Ben Amor, Mohamed +4 more
core +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Adjuvant role of macrophages in stem cell-induced cardiac repair in rats
Experimental and Molecular Medicine, 2018 Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing
Soo yeon Lim +7 more
doaj +1 more source
The future of public sector funding of regeneration project in England [PDF]
, 1999 This report describes the policy framework through which urban regeneration is promoted and highlights the difficulties encountered in co-ordinating the current public funding initiatives to secure effective urban regeneration and maximise value for ...
Greenhalgh, Paul, Hargreaves, Sylvia
core
Studying Planarian Regeneration Aboard The International Space Station Within The Student Space Flight Experimental Program [PDF]
, 2018 The growing possibilities of space travel are quickly moving from science fiction to reality. However, to realize the dream of long-term space travel, we must understand how these conditions affect biological and physiological processes.
Bartee, C. +3 more
core +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Industrial water management by multiobjective optimization: from individual to collective solution through eco-industrial parks. [PDF]
, 2012 Industrial water networks are designed in the first part by a multiobjective optimization strategy, where fresh water, regenerated water flow rates as well as the number of network connections (integer variables) are minimized.
Azzaro-Pantel, Catherine +4 more
core +2 more sources