Results 61 to 70 of about 549,859 (269)

Human α-synuclein aggregation activates ferroptosis leading to parvalbumin interneuron degeneration and motor learning impairment

Communications Biology
The accumulation of α-synuclein induces neuronal loss in midbrain nuclei and leads to the disruption of motor circuits, while the pathology of α-synuclein in cortical regions remains elusive.
Borui Zhang, Kai Chen, Yelin Dai, Xi Luo, Ziwei Xiong, Weijia Zhang, Xiaodan Huang, Kwok-Fai So, Li Zhang   +8 more
doaj   +1 more source

Adjuvant role of macrophages in stem cell-induced cardiac repair in rats

Experimental and Molecular Medicine, 2018
Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing
Soo yeon Lim, Dong Im Cho, Hye-yun Jeong, Hye-jin Kang, Mi Ra Kim, Meeyoung Cho, Yong Sook Kim, Youngkeun Ahn   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Walri

Regeneration
A multimodal collaboration between artists, writers, and scholars. This piece emerged from an expedition to the Arctic archipelago as part of the Arctic Circle Residency in Autumn 2022.
Candace N Jensen, Hannah Larrabee, Harley Cowan   +2 more
doaj   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Intimacy

Regeneration
A multimodal collaboration between artists, writers, and scholars. This piece emerged from an expedition to the Arctic archipelago as part of the Arctic Circle Residency in Autumn 2022.
Alexandra Lockhart, Dianne Chisholm, Hannah Larrabee, Jia-Jen Lin, Sarah Gerats, Zoriça Kelly Markovich   +5 more
doaj   +2 more sources

A high-glucose diet affects Achilles tendon healing in rats

Scientific Reports, 2017
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer   +10 more
doaj   +1 more source

Periodontal regeneration [PDF]

Australian Dental Journal, 2009
AbstractThe ultimate goal of periodontal therapy is the regeneration of the tissues destroyed as a result of periodontal disease. Currently, two clinical techniques, based on the principles of “guided tissue regeneration” (GTR) or utilization of the biologically active agent “enamel matrix derivative” (EMD), can be used for the regeneration of ...
openaire   +5 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Arts of Repair: A Conversation with Yhonnie Scarce and Craig Santos Perez

Regeneration
A dialogue that took place on 5 December, 2023, between the Kokatha and Nukunu sculptural artist and curator Yhonnie Scarce and the CHamoru poet and essayist Craig Santos Perez. It was facilitated by Rebecca Macklin and Susanne Ferwerda. 
doaj   +2 more sources