MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta
Molecular Therapy: Nucleic Acids, 2019 Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis and angiogenesis via targeting the important mediators.
Le Yang +6 more
doaj
Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies [PDF]
, 2021 Pedro Morouço +2 more
openalex +1 more source
Mimicking developmental biology to regenerate the intervertebral disc
, 2018 Nearly three-quarters of the human population will be affected by low back pain at some stage in their lives. While this condition is multifactorial, intervertebral disc (IVD) degeneration is one of its major causes, involved in at least 40% of chronic (low) back pain cases.
openaire +3 more sources
Advanced Functional Materials, EarlyView.Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan +4 more
wiley +1 more source
Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration
iScience, 2019 Summary: The adult zebrafish is capable of regenerating heart muscle, resolving collagen tissue, and fully restoring heart function throughout its life. In this study, we show that the highly upregulated, epicardium-enriched microRNA let-7i functions in ...
Ashley M. Smith +3 more
doaj
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
Nature Communications, 2017 DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that ...
Silvia Monteagudo +7 more
doaj +1 more source
Optimal Construction of Regenerating Code through Rate-matching in Hostile Networks [PDF]
arXiv, 2015 Regenerating code is a class of code very suitable for distributed storage systems, which can maintain optimal bandwidth and storage space. Two types of important regenerating code have been constructed: the minimum storage regeneration (MSR) code and the minimum bandwidth regeneration (MBR) code.
arxiv
Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology [PDF]
, 2021 Fabiola Marino +8 more
openalex +1 more source
Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
Advanced Functional Materials, EarlyView.Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang +5 more
wiley +1 more source
AI-driven control of bioelectric signalling for real-time topological reorganization of cells [PDF]
arXivUnderstanding and manipulating bioelectric signaling could present a new wave of progress in developmental biology, regenerative medicine, and synthetic biology. Bioelectric signals, defined as voltage gradients across cell membranes caused by ionic movements, play a role in regulating crucial processes including cellular differentiation, proliferation,
arxiv