Results 81 to 90 of about 424,495 (312)

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. [PDF]

, 2018
The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Andrusiak, Matthew G, Cherra, Salvatore J, Chisholm, Andrew D, Jin, Yishi, Kim, Kyung Won, Kurup, Naina, Park, Seungmee, Piggott, Christopher A, Tang, Ngang Heok, Wu, Zilu, Zhu, Ming   +10 more
core   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Mediators of Inflammation, 2017
Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts, Jessie Van houcke, Lien Andries, Lies De Groef, Lieve Moons   +4 more
doaj   +1 more source

Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis?

Rheumatology and Therapy, 2020
Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence of obesity and aging of the population are two factors that suggest that the impact of ...
Rik J. Lories, Silvia Monteagudo
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus

Cell Reports, 2014
Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the postnatal thymus has been inferred, but their identity has remained ...
Kahlia Wong, Natalie L. Lister, Marco Barsanti, Joanna M.C. Lim, Maree V. Hammett, Danika M. Khong, Christopher Siatskas, Daniel H.D. Gray, Richard L. Boyd, Ann P. Chidgey   +9 more
doaj   +1 more source

Resilience of New Zealand indigenous forest fragments to impacts of livestock and pest mammals [PDF]

, 2011
A number of factors have combined to diminish ecosystem integrity in New Zealand indigenous lowland forest fragments surrounded by intensively grazed pasture.
Barker, Gary M., Burns, Bruce, Didham, Raphael, Dodd, Mike, Innes, John G., King, Carolyn M., Smale, Mark, Watts, Corinne   +7 more
core  

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo [PDF]

, 2016
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their ...
A Carleton, A Nissant, A Suli, AB Neef, AC Barber, BE Reese, BW Jones, CR Shields, DA Laplagne, E Strettoi, F Rossi, FD D’Orazi, G Salbreux, H Pisharath, HT Cline, J Schindelin, JM Davison, JR Lenkowski, JR Sanes, JZ Parrish, K Eliasieh, KA Michelsen, KM Christian, KM Kwan, M Takechi, M Takechi, MA Raven, MA Samuel, MJ Phillips, MS Singh, N Cuenca, N Toni, PR Johns, R Christensen, R Vroman, RA Poché, RE MacLaren, S Michalakis, S Yogev, SC Suzuki, SSP Magavi, T Puthussery, T Yoshimatsu, TS Vihtelic, W Haq, WB Thoreson, X Liu, Y Ueki, YN Li, YW Peng   +49 more
core   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host

Aging and Cancer, EarlyView.
Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Reihaneh Safavi‐Sohi, Daniel D. Hu, Elizabeth I. Harper, Gena Dominique, Wanrui Wang, Jeffrey Johnson, Marwa Asem, William Milosevich, Julia Florek Carlson, Yunpeng Bai, Jinmin Miao, Zhong‐Yin Zhang, Matthew M. Champion, M. Sharon Stack   +17 more
wiley   +1 more source

Identification of the orphan gene Prod 1 in basal and other salamander families. [PDF]

, 2015
The urodele amphibians (salamanders) are the only adult tetrapods able to regenerate the limb. It is unclear if this is an ancestral property that is retained in salamanders but lost in other tetrapods or if it evolved in salamanders.
Brockes, JP, Garza-Garcia, A, Gates, PB, Geng, J, Guenther, S, Kuenne, C, Kumar, A, Looso, M, Zhang, P   +8 more
core   +1 more source