Results 41 to 50 of about 743,425 (285)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Morphological changes of the nerve after restorative treatment using electric welding technology (experimental study)

open access: yesЕндоваскулярна нейрорентгенохірургія, 2019
Objective – to study morphological features regenerative nerve neuroma after a complete intersection and restorative surgery with the use of electric welding technology. Materials and methods.
V. Yu. Molotkovets
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Joint Power Splitting and Secure Beamforming Design in the Multiple Non-regenerative Wireless-powered Relay Networks

open access: yes, 2015
The physical-layer security issue in the multiple non-regenerative wireless-powered relay (WPR) networks is investigated in this letter, where the idle relay is treated as a potential eavesdropper. To guarantee secure communication, the destination-based
Feng, Suili   +2 more
core   +1 more source

Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury [PDF]

open access: yes, 2017
Macro-sieve electrodes were implanted in the sciatic nerve of five adult male Lewis rats following spinal cord injury to assess the ability of the macro-sieve electrode to interface regenerated peripheral nerve fibers post-spinal cord injury. Each spinal
Birenbaum, Nathan K   +2 more
core   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Establishing PNB-qPCR for quantifying minimal ctDNA concentrations during tumour resection

open access: yesScientific Reports, 2017
The analysis of blood plasma or serum as a non-invasive alternative to tissue biopsies is a much-pursued goal in cancer research. Various methods and approaches have been presented to determine a patient’s tumour status, chances of survival, and response
T. Ehlert   +10 more
doaj   +1 more source

Linear Precoders for Non-Regenerative Asymmetric Two-way Relaying in Cellular Systems [PDF]

open access: yes, 2013
Two-way relaying (TWR) reduces the spectral-efficiency loss caused in conventional half-duplex relaying. TWR is possible when two nodes exchange data simultaneously through a relay.
Budhiraja, Rohit   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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