Results 51 to 60 of about 743,425 (285)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Optimizing System Efficiency and Reliability: Integrating Semi-Markov Processes and Regenerative Point Techniques for Maintenance Strategies in Plate Manufacturing

WSEAS TRANSACTIONS ON MATHEMATICS
This paper offers a modeling methodology to evaluate similar systems’ performance and optimize system effectiveness with customized maintenance plans. This strategy, which combines regeneration point techniques with semi-Markov processes, is used to assess a plate manufacturing company’s system.
Prawar Prawar, Anjali Naithani, H. D. Arora, Ekata Ekata   +3 more
openaire   +1 more source

Design study of a novel regenerative pump using experimental and numerical techniques [PDF]

, 2010
This paper presents a numerical and experimental analysis of a new regenerative pump design. The complex flow-field within regenerative pumps represents a significant challenge to previous published mathematical models. The new pump design incorporates a
Baumgartner, B., Quail, Francis J., Stickland, M.T.   +2 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up

Journal of Experimental Orthopaedics, 2018
Background Conservative therapies for the treatment of knee degenerative processes are used before resorting to surgery; nonetheless, they may offer only short-term benefits. Encouraging preliminary results have been reported using mesenchymal stem cells
A. Russo, D. Screpis, S. L. Di Donato, S. Bonetti, G. Piovan, C. Zorzi   +5 more
doaj   +1 more source

Testing Luminescence Dating Methods for Small Samples from Very Young Fluvial Deposits [PDF]

, 2019
The impetus behind this study is to understand the sedimentological dynamics of very young fluvial systems in the Amazon River catchment and relate these to land use change and modern analogue studies of tidal rhythmites in the geologic record.
Archer, Allen W., Caldas, Marcellus M., Huot, Sebastien, Spencer, Joel Q. G.   +3 more
core   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Stochastic modelling and reliability analysis of a three-unit non-identical repairable HVAC system with warranty considerations

Discover Sustainability
This paper presents a stochastic model for a three-unit, non-identical, repairable HVAC system comprising two identical air-conditioning units operating in parallel for cooling and a distinct ventilation unit for fresh air circulation.
Vibhu Singhal, Indeewar Kumar, Gitanjali
doaj   +1 more source

Oncological safety of stromal vascular fraction enriched fat grafting in two-stage breast reconstruction after nipple sparing mastectomy: long-term results of a prospective study [PDF]

, 2018
OBJECTIVE: Autologous fat transfer (AFT) is commonly used to treat implant palpability and prevent fibrosis and thinning in mastectomy skin flaps.
Badylak, S., Barellini, L., Calabrese, C., Casella, D., D'ermo, G., Di Taranto, G., Fausto, A., Gaggelli, I., Kothari, A., Lo Torto, F., Marcasciano, M., Ribuffo, D., Sordi, S., Tarallo, M.   +13 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source