Results 61 to 70 of about 4,842,470 (311)
Estimation of optimal dynamic treatment regimes [PDF]
Clinical Trials, 2014 Background Recent advances in medical research suggest that the optimal treatment rules should be adaptive to patients over time. This has led to an increasing interest in studying dynamic treatment regime, a sequence of individualized treatment rules, one per stage of clinical intervention, which maps present ...
Ying-Qi, Zhao, Eric B, Laber
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Dynamic Hedging in Markov Regimes Switching [PDF]
, 2010 This article proposes a bivariate markov switching dynamic conditional correlation model for estimating the optimal hedge ratio between spot and futures contracts. It considers the cointegration between series and allows to capture the leverage effect in return equation.
Wagner Oliveira Monteiro +1 more
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Analysis of Time Reversible Born-Oppenheimer Molecular Dynamics
Entropy, 2013 We analyze the time reversible Born-Oppenheimer molecular dynamics (TRBOMD) scheme, which preserves the time reversibility of the Born-Oppenheimer molecular dynamics even with non-convergent self-consistent field iteration. In the linear response regime,
Lin Lin, Jianfeng Lu, Sihong Shao
doaj +1 more source
On the Dynamical Regimes of Pattern-Accelerated Electroconvection [PDF]
Scientific Reports, 2016 AbstractRecent research has established that electroconvection can enhance ion transport at polarized surfaces such as membranes and electrodes where it would otherwise be limited by diffusion. The onset of such overlimiting transport can be influenced by the surface topology of the ion selective membranes as well as inhomogeneities in their ...
Davidson, Scott M. +2 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Field-resolved high-order sub-cycle nonlinearities in a terahertz semiconductor laser
Light: Science & Applications, 2021 Two-dimensional terahertz strong-field spectroscopy reveals wave-mixing processes up to eighth order in a free-running quantum cascade laser, unraveling its sub-cycle gain dynamics and nonlinearities in a regime of negative absorption.
J. Riepl +13 more
doaj +1 more source