Results 91 to 100 of about 3,020,795 (297)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Inequality, Fiscal Capacity and the Political Regime: Lessons from the Post-Communist Transition [PDF]

Using panel data for twenty-seven post-communist economies between 1987-2003, we examine the nexus of relationships between inequality, fiscal capacity (defined as the ability to raise taxes efficiently) and the political regime. Investigating the impact
Christopher Gerry, Tomasz Mickiewicz
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optical Absorption Line Shape of a Λ-Type Three-Level Semiconductor Quantum Dot: Roles of Transition Dipole Moment and Relaxation Rate

JIF (Jurnal Ilmu Fisika)
The optical absorption of an isolated Λ-type three-level semiconductor quantum dot under continuous-wave excitation was investigated theoretically using a semiclassical density-matrix approach.
Bintoro Siswo Nugroho, Arik Ramadhan, Asifa Asri   +2 more
doaj   +1 more source

The Regime Shift Associated with the 2004-2008 US Housing Market Bubble.

PLoS ONE, 2016
The Subprime Bubble preceding the Subprime Crisis of 2008 was fueled by risky lending practices, manifesting in the form of a large abrupt increase in the proportion of subprime mortgages issued in the US.
James Tan, Siew Ann Cheong
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Inhibitory synaptic timescales drive oscillatory regime transitions in recurrent excitatory-inhibitory networks

Physical Review Research
In recurrent cortical networks, inhibitory kinetics are often assumed to tune oscillation frequency continuously. Using a recurrent excitatory-inhibitory (E-I) model with fixed excitatory synaptic dynamics, we systematically vary inhibitory decay time ...
Siamak Kheiri, Saeed Taghavi, Matjaž Perc, Alireza Valizadeh   +3 more
doaj   +1 more source

Elucidating the in-process interfacial friction regime and thermal responses during inertia friction welding of dissimilar superalloys

Journal of Materials Research and Technology
Inertia friction welding (IFW) is a robust joining technique, particularly for hybrid structures composed of similar or dissimilar alloys. The highly transient thermal responses during friction heating produce variations in heat generation and ...
Tianxiang Tang, Qingyu Shi, Chunbo Zhang, Wu Liang, Jun Zhou, Gong Zhang, Gaoqiang Chen   +6 more
doaj   +1 more source

The Impact of the Applied Exchange Rate Regimes on the Internal Balance of Transition Countries

ECONOMICS, 2017
One of the key goals of the economic policy makers of every country is to achieve internal and external balance. An unavoidable segment of the analysis concerning the achievement of internal and external balance is certainly the influence of the exchange
Vujanić Vlado, Gligorić Dragan
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source