Results 131 to 140 of about 2,053,309 (328)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Actors, Interests and Strategies of Brazilian Foreign Policy on Biofuels
Brazilian Political Science Review, 2012 This article aims to examine how the entry of biofuels into Brazil’sinternational agenda came about and which actors and interests have influencedthe formulation of the Brazilian foreign policy on biofuels.
Marcelo de Almeida Medeiros +1 more
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Etude du regime transitoire de demarrage rapide d'une pompe centrifuge
, 1993 Naceur Ghelici
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Regime-Switched Neural Networks: Flow Stress Modeling Strategy of 310s Stainless Steel During Hot Deformation [PDF]
, 2021 Jeongho Cho, Shin-Hyung Song
openalex +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Commentary on al-Azhar Declaration in Support of the Arab revolutions
Amsterdam Law Forum, 2012 Al-Azhar, one of the first universities in the world, is traditionally considered the chief centre of Arabic literature and Islamic learning in the world.
Adel Maged
doaj