Results 31 to 40 of about 12,492,395 (249)

Jubilee Memorial, 1857-1907: the Story of the Church and First Fifty Years of the Diocese of Huron [PDF]

open access: yes, 1907
A history of the Anglican diocese of Huron in London, Ontario.https://scholar.uwindsor.ca/swoda-windsor-region/1047/thumbnail ...
Richardson, J. B.
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

open access: yesFEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

open access: yesFEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner   +7 more
wiley   +1 more source

Windsor, Essex, And Lake Shore Railway: Criticisms And Charges, 1933 [PDF]

open access: yes, 1933
Criticism and charges against the Windsor, Essex and Lake Shore Railway, dated January 19th, 1933; also the responses to these criticisms; the Windsor, Essex, and Lake Shore Railway folded on September 15th, 1932.https://scholar.uwindsor.ca/swoda-windsor-
Anonymous
core   +1 more source

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Greater Windsor Directory of Manufacturers 1958 [PDF]

open access: yes, 1958
Directory of industries and a cross-indexed list of products manufactured; includes a statistical profile of Windsor.https://scholar.uwindsor.ca/swoda-windsor-region/1036/thumbnail ...
Greater Windsor Industrial Commission
core   +1 more source

The Pacific Rim: Region or regions?

open access: yesPapers of the Regional Science Association, 1990
Given the dynamic nature of the Pacific Rim, the Pacific Regional Science Conference Organization (PRSCO) has a unique opportunity to both grow with the region and contribute solutions to the problems which come with growth. This paper first examines some of the economic attributes of the Pacific Region and then explores some of the challenges and ...
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

MS4 Resource: BMP Crosswalk [PDF]

open access: yes, 2017
A cross-walk to assist designers and modelers to match common BMPs identified in the MA and NH Stormwater Manual with the BMPs modeled in the MS4 permit and documented in appendix
EPA Region 1   +1 more
core   +1 more source

REGIONAL THEORY AND REGIONAL MODELS

open access: yesPapers in Regional Science, 1962
The ideas outlined in this paper are tentative and only partially developed. They have arisen very much as a response to the deficiencies in existing regional models. Whether this particular structure can lead to added order and power in such models remains to be demonstrated.
openaire   +2 more sources

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