Results 31 to 40 of about 12,492,395 (249)
Jubilee Memorial, 1857-1907: the Story of the Church and First Fifty Years of the Diocese of Huron [PDF]
A history of the Anglican diocese of Huron in London, Ontario.https://scholar.uwindsor.ca/swoda-windsor-region/1047/thumbnail ...
Richardson, J. B.
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Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek+15 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Windsor, Essex, And Lake Shore Railway: Criticisms And Charges, 1933 [PDF]
Criticism and charges against the Windsor, Essex and Lake Shore Railway, dated January 19th, 1933; also the responses to these criticisms; the Windsor, Essex, and Lake Shore Railway folded on September 15th, 1932.https://scholar.uwindsor.ca/swoda-windsor-
Anonymous
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Autophagy in cancer and protein conformational disorders
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Greater Windsor Directory of Manufacturers 1958 [PDF]
Directory of industries and a cross-indexed list of products manufactured; includes a statistical profile of Windsor.https://scholar.uwindsor.ca/swoda-windsor-region/1036/thumbnail ...
Greater Windsor Industrial Commission
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The Pacific Rim: Region or regions?
Given the dynamic nature of the Pacific Rim, the Pacific Regional Science Conference Organization (PRSCO) has a unique opportunity to both grow with the region and contribute solutions to the problems which come with growth. This paper first examines some of the economic attributes of the Pacific Region and then explores some of the challenges and ...
openaire +2 more sources
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang+2 more
wiley +1 more source
MS4 Resource: BMP Crosswalk [PDF]
A cross-walk to assist designers and modelers to match common BMPs identified in the MA and NH Stormwater Manual with the BMPs modeled in the MS4 permit and documented in appendix
EPA Region 1+1 more
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REGIONAL THEORY AND REGIONAL MODELS
The ideas outlined in this paper are tentative and only partially developed. They have arisen very much as a response to the deficiencies in existing regional models. Whether this particular structure can lead to added order and power in such models remains to be demonstrated.
openaire +2 more sources