Results 41 to 50 of about 12,492,395 (249)
Architecture and the Built Environment, 2017 In recent decades the Netherlands has seen an increase in the use of regional design-led practices in national indicative planning. Despite this, the interrelations between design and planning decision making are not well understood and attempts to involve the expertise and ambition of designers in planning have had unclear outcomes.
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A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
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FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Review of Erosion and Sedimentation Control Programs in the Piscataqua Region [PDF]
, 2010 The Piscataqua Region Estuaries Partnership (PREP) seeks to minimize adverse impacts to water resources associated with construction site development activities. In order to achieve this goal, PREP must understand the strengths and weaknesses of existing
Clifford, Jeff +3 more
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FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Spotlight on Essex County: 2010 Fall [PDF]
, 2010 Articles about Essex County on topics such as local aviators, grain silos, lost communities, toll gates, pawpaw and Jesuit pear trees, wineries.https://scholar.uwindsor.ca/swoda-windsor-region/1069/thumbnail ...
Essex Free Press
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Regions, Regionalisms and Identities
, 2017 Abstract This chapter seeks to interrogate the transformation of regions, in order to tease out the sometimes paradoxical relationship between various approaches to conceptualising space. It aims to connect discussions on different kinds of regions and regionalisms, considering both deinstitutionalisation and institutionalisation processes. The chapter
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FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source