Results 41 to 50 of about 167,870,404 (256)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Calcaneal Ultrasound Attenuation: Does the Region of Interest and Loading Influence the Repeatability of Measurement? [PDF]

Current calcaneal quantitative ultrasound systems assess different regions of interest (ROI), under different levels of lower limb loading, yield different parameter values, and are likely prone to different levels of error.
Langton, Christian M, Robertson, Aaron P., Jones, Brendan J., Robertson, Aaron P, Wearing, Scott C., Jones, Brendan J, Langton, Christian M., Wearing, Scott C   +7 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

DETECTING DIGITAL IMAGE FORGERIES USING RE-SAMPLING BY AUTOMATIC REGION OF INTEREST (ROI) [PDF]

ICTACT Journal on Image and Video Processing, 2012
Nowadays, digital images can be easily altered by using high-performance computers, sophisticated photo-editing, computer graphics software, etc. It will affect the authenticity of images in law, politics, the media, and business.
P. Subathra, A. Baskar, D. Senthil Kumar
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Shearlet-based regularized ROI reconstruction in fan beam computed tomography

, 2015
Region-of-interest (ROI) reconstruction in computed tomography (CT) is a problem receiving increasing attention in the medical imaging community, due to its potential to lower exposure to X-ray radiation and to reduce the scanning time.
Bubba T. , A., Labate, D., BONETTINI, Silvia, Goossens, B., Zanghirati, G.   +4 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Efficient Method for POI/ROI Discovery Using Flickr Geotagged Photos

ISPRS International Journal of Geo-Information, 2018
In the era of big data, ubiquitous Flickr geotagged photos have opened a considerable opportunity for discovering valuable geographic information. Point of interest (POI) and region of interest (ROI) are significant reference data that are widely used in
Chiao-Ling Kuo, Ta-Chien Chan, I-Chun Fan, Alexander Zipf   +3 more
doaj   +1 more source

Vehicle Detection Based on Multifeature Extraction and Recognition Adopting RBF Neural Network on ADAS System

Complexity, 2020
A region of interest (ROI) that may contain vehicles is extracted based on the composite features on vehicle’s bottom shadow and taillights by setting a gray threshold on vehicle shadow region and a series of constraints on taillights.
Xuewen Chen, Huaqing Chen, Huan Xu
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source