Results 91 to 100 of about 543,985 (300)

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Regional Autonomy in Nigeria: Influence on Dynamics of Governance and National Integration

Social Sciences
This article analyzes the significance of regional autonomy in Nigeria and its impact on both national integration processes and governance issues, based on the empirical argument for the autonomy of ethnically diverse regions.
Olugbenga James, Sadık Akyar
doaj   +1 more source

Nature and determinants of productivity growth of foreign subsidiaries in Central and East European countries [PDF]

, 2006
The paper examines the determinants of productivity growth in foreign manufacturing subsidiaries in five Central and East European (CEE) countries by analysing patterns of control, nature of firms' capabilities and firms' market orientation.
Majcen, M., Radošević, S., Rojec, M.
core  

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Political Economy of East Asian Regional Integration and Cooperation [PDF]

In the last decade, East Asia has engaged in constructing numerous mechanisms to enhance regional cooperation in the areas of trade and finance. However' the region's economic architecture exhibits certain idiosyncrasies such as an eclectic institutional
Katada, Saori N.
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

THE IMPACT OF REGIONAL AUTONOMY ON REGIONAL DEVELOPMENT

International Journal of Social Service and Research
The objective of this research is to analyze the impact of regional autonomy on regional development. This study aims to understand how the implementation of regional autonomy policies, which grant greater authority to local governments in managing resources and making decisions, influences various aspects of regional development.
M. Ikrar Budijaya, Yanto Heryanto
openaire   +1 more source

ANALISIS PENGARUH DESENTRALISASI FISKAL TERHADAP PDRB (STUDI KASUS KABUPATEN DAN KOTA DI PROVINSI JAWA TENGAH PERIODE TAHUN 2009-2014) [PDF]

, 2016
The change of centralization system becomes decentralization began with the enactment of law No. 22 of 1999 about local governance and law No. 25 of 1999 regarding financial equalization between the Center and regions. With the Act based on the Indonesia
POERWONO, Dwisetia, YUSTISIA, Pria Pandu
core