Results 51 to 60 of about 1,570,725 (302)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Changing rainfall pattern in Northeast Thailand and implications for cropping systems adaptation [PDF]

, 2015
In Northeast Thailand, about 80% of the 20 million inhabitants are engaged in rainfed agriculture. Climate vagaries combined with coarse-textured sandy and unevenly distributed saline soils explain low agriculture yields and the endemic relative poverty ...
Lacombe, Guillaume, Polthanee, Anan, Trébuil, Guy   +2 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Comparing random forest flood frequency analysis with regional flood frequency, Creager and SCS in Doab-Qazanchi, Kermanshah [PDF]

Journal of Applied Research in Water and Wastewater
Due to climate change and rising global temperature, the occurrence of extreme floods and drought events has intensified. In this regard, in 2019, heavy rainfall occurred in Kermanshah province.
Maryam Hafezparast, Sadaf Gord, Rasool Ghobadian   +2 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The design rainfall based on regional frequency analysis using tl-moment method

Jurnal Sumber Daya Air, 2016
The designs rainfall were estimated with the regional frequency analysis provides benefits to a dataset that has a limited amount of data. Minimum data used in calculating the amount of design rainfall has a very large error for higher return period ...
Segel Ginting, William M Putuhena
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regional Frequency Analysis of Annual Total Rainfall in Pakistan Using L-Moments

NUST Journal of Engineering Sciences, 2017
This study presents the estimation of regional quantiles of Annual Total Rainfall (ATR) for 30 meteorological stations using index flood procedure based on L-moments. Discordancy measure based on L-moments was used to screen the ATR.
Ishfaq Ahmad, Aamir Abbas, Muhammad Fawad, Aamir Saghir   +3 more
doaj   +1 more source

The use of historical information for regional frequency analysis of extreme skew surge [PDF]

Natural Hazards and Earth System Sciences, 2018
The design of effective coastal protections requires an adequate estimation of the annual occurrence probability of rare events associated with a return period up to 103 years. Regional frequency analysis (RFA) has been proven to be an applicable way
R. Frau, R. Frau, M. Andreewsky, P. Bernardara   +3 more
doaj   +1 more source

Frequency domain modelling of random wound motor windings for insulation stress analysis [PDF]

, 2006
The use of conventional low voltage induction motors fed by pulse width modulated (PWM) inverters has begun to present important problems. These waveforms consist of steep-fronted pulses having very short rise times (about 100 ns in modern IGBT bridges ...
Amarís Duarte, Hortensia Elena, Martínez Tarifa, Juan Manuel, Sanz Feito, Javier   +2 more
core   +3 more sources