Results 61 to 70 of about 1,570,725 (302)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rainfall frequency analysis for ungauged sites using satellite precipitation products [PDF]

, 2017
The occurrence of extreme rainfall events and their impacts on hydrologic systems and society are critical considerations in the design and management of a large number of water resources projects.
Gado, TA, Hsu, K, Sorooshian, S
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Global application of a regional frequency analysis to extreme sea levels [PDF]

Natural Hazards and Earth System Sciences
Coastal regions face increasing threats from rising sea levels and extreme weather events, highlighting the urgent need for accurate assessments of coastal flood risk.
T. P. Collings, N. D. Quinn, I. D. Haigh, I. D. Haigh, J. Green, J. Green, I. Probyn, H. Wilkinson, S. Muis, S. Muis, W. V. Sweet, P. D. Bates, P. D. Bates   +12 more
doaj   +1 more source

Regional Rainfall Frequency Analysis

, 2020
Frequency analysis is a vital tool when nding a well-suited probability distributionin order to predict extreme rainfall. The regional frequency approach have beenused for determination of homogeneous regions, using 11 sites in Skane, Sweden. Todescribe maximum annual daily rainfall, the Generalized Logistic (GLO), GeneralizedExtreme Value (GEV ...
Rudberg, Olov, Bezaatpour, Daniel
openaire   +1 more source

Mass fluxes and isofluxes of methane (CH4) at a New Hampshire fen measured by a continuous wave quantum cascade laser spectrometer [PDF]

, 2012
We have developed a mid‐infrared continuous‐wave quantum cascade laser direct‐absorption spectrometer (QCLS) capable of high frequency (≥1 Hz) measurements of 12CH4 and 13CH4 isotopologues of methane (CH4) with in situ 1‐s RMS image precision of 1.5 ...
Crill, Patrick M., Goodrich, Jordan P., Lee, Ben H., McManus, J. Barry, Nelson, David D., Santoni, Gregory W., Varner, Ruth K., Wofsy, Steven C., Zahniser, Mark S.   +8 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Regional approach for the analysis of annual maximum daily precipitation in northern Morocco

Weather and Climate Extremes, 2018
Information on extreme rainfall frequencies is required for Urban Drainage (UD) networks design. In this paper, the Regional Frequency Analysis (RFA), based on the L-moments, is used to: (i) analyze the trend of Annual Maximum Precipitation (AMP) over ...
Mohammed Moujahid, Laila Stour, Ali Agoumi, Amina Saidi   +3 more
doaj   +1 more source

Regional Flood Frequency Analysis Around Seyhan Basin

, 2022
In the 21st century, floods, which are frequent disasters due to the increasing temperature all over the world together with the global climate change, and consequently heavy, sudden precipitations and sudden snowmelt, cause great economic, ecological, and environmental damage and even loss of life.
Yılmaz, S. Utku, Çiltaş, Efe, Bakar, Hamza, Eldayıh Kanber, Yasemin, Öz, Müberra, Kesmez, Ekrem, Önöz, Bihrat   +6 more
openaire   +1 more source

Tidal dynamics on the North Patagonian Argentinean Gulfs [PDF]

, 2017
Semidiurnal (M2, S2, N2 and K2), diurnal (K1,O1 and P1) and quarter-diurnal (M4, MN4 and MS4) barotropic tides over the North Patagonian Gulfs of Argentina: San Matías, (SMG), Nuevo (NG) and San José (SJG) are examined using a regional numerical model ...
Palma, Elbio Daniel, Tonini, Mariano Hernan   +1 more
core   +1 more source