Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Too Mex for the Masses: Bringing Mexican Regional Music to Market [PDF]
: This article explores the exclusion of Mexican regional music from major marketing and promotional efforts within the domestic music industry, and what that elision reveals about dominant and competing claims on “Latino” ethnic identity.
Morrison, Amanda Maria
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Public libraries and forming regional identity (Republic of Bashkortostan)
The role of the public libraries in forming the regional identity is shown.
R. A. Gilmijanova
doaj
Regional identity and culture in intercompany networks – a case of Transdanubian winery networks [PDF]
Nowadays a wide range of cooperations can be observed from strategic alliances through networks of suppliers till clusters, due to the fact that market players through collaboration can gain competitive advantages, can facilitate their market penetration
Brányi, Árpád, Tamándl, László
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Heterogeneity, Politics of Ethnicity, and Multiculturalism What is a Viable Framework for Indonesia? [PDF]
Indonesia is a plural society that consists of several hundred ethnic and sub-ethnic groups. One of its generic characteristics is heterogeneity. In the last ten years after the implementation of regional autonomy, we have witnessed the emergence of ...
Lan, T. J. (Thung)
core +3 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Regional consciousness and the regional identity [PDF]
U radu su sa geografskog stanovišta definisani pojmovi regionalna svest i regionalni identitet. Ukazano je na neke karakteristike regionalnog pristupa u analizi tih pojmova koje prevazilaze direktnu i jednostavnu percepciju geoprostora i zamenjuju je kompleksnijim pogledom na geografsku regiju.
Šabić, Dejan, Pavlović, Mila
openaire
Local Wisdom for Ecotourism Development in Bogor [PDF]
The development that occurred in the Bogor city is currently feared will have an impact on shifting authenticity of existing regional identity. Regional identity that still exists is one manifestation of local wisdom carried out by the community.
Avenzora, R. (Ricky) +2 more
core

